Maresi M P, Baldi L, Balatresi L, Bogi G, Civello T, Cosimi A, De Santis R, Guarnotta M, Baisi F, Parente A
Divisione Ostetrico Ginecologica, Ospedale di Livorno.
Ann Ostet Ginecol Med Perinat. 1990 Nov-Dec;111(6):393-9.
The pharmaco therapeutic effect of polydeoxyribonucleotide vaginal suppositories in two dosages (PDRN 1,65 mg and PDRN 5 mg)* on vaginal dystrophy was studied. 40 women, aged more than forty, in surgical or physiological climacteric with cervico-vaginal dystrophy were examined. The study was carried out according to the double-blind method, randomized, between groups. Both treatments produced important ameliorations of subjective symptomatology and objective signs. No significant difference emerged between the two preparations. PDRN was proved to be a valid alternative to local hormonal therapies.
研究了两种剂量（1.65毫克聚脱氧核糖核苷酸和5毫克聚脱氧核糖核苷酸）的聚脱氧核糖核苷酸阴道栓剂对阴道营养不良的药物治疗效果。对40名年龄超过40岁、处于手术或生理性更年期且患有宫颈阴道营养不良的女性进行了检查。该研究采用双盲法，在组间进行随机分组。两种治疗方法均使主观症状和客观体征有了显著改善。两种制剂之间未出现显著差异。聚脱氧核糖核苷酸被证明是局部激素疗法的有效替代方法。
