De Luca Brunori I, Urbano M, Romani L, Tarani A, Felipetto R, Battini L, Amato A, Andreoni P
Istituto di Clinica Ostetrica e Ginecologia, Università di Pisa.
Ann Ostet Ginecol Med Perinat. 1990 Nov-Dec;111(6):379-87.
Thirty patients in fertile age affected by ectropion were treated with Polydeoxyribonucleotide (PDRN) (*) vaginal suppositories for 24 days. No other local or general therapy was allowed. The following parameters were evaluated: local symptomatology, tolerability and compliance, vaginal cytology, colposcopic examination, bioptic sampling of affected area prior to and after treatment, and local immune response. The results show the efficacy of PDRN. In fact, after the treatment: reduction of subjective symptomatology with decrease of average score for each symptom; excellent or good tolerability and acceptability; reduced inflammation; increased iodine-dark areas; reestablishment of normal balance in T- and B-lymphocytic populations have been found.
30名患有外翻的育龄患者接受了聚脱氧核糖核苷酸（PDRN）（*）阴道栓剂治疗，为期24天。不允许进行其他局部或全身治疗。评估了以下参数：局部症状、耐受性和依从性、阴道细胞学检查、阴道镜检查、治疗前后患区的活检取样以及局部免疫反应。结果显示了PDRN的疗效。事实上，治疗后：主观症状减轻，各症状平均评分降低；耐受性和可接受性良好或极佳；炎症减轻；碘染色区增加；T淋巴细胞和B淋巴细胞群体恢复了正常平衡。
