Salam A, Eyres K, Cleary J
Orthopaedic Department, King Edward VII Hospital, Sheffield.
Br J Clin Pract. 1990 Dec;44(12):652-4.
Langerhans' cell histiocytosis (LCH) is an extremely heterogeneous disorder which is uncommon, making therapeutic guidelines difficult. The malignant features seen in this case have been described presenting in the skin but not in the bone. Although pathological fractures through bone affected by eosinophilic granuloma have been described, this is the first reported case of LCH with malignant features presenting in such a way.
朗格汉斯细胞组织细胞增多症（LCH）是一种极为异质性的疾病，较为罕见，这使得治疗指南难以制定。该病例中所见的恶性特征已被描述为出现在皮肤而非骨骼中。尽管已有关于嗜酸性肉芽肿累及的骨骼发生病理性骨折的报道，但这是首例以这种方式呈现恶性特征的LCH病例报告。
