前列环素（PGI2）通过细胞色素P450依赖性环氧化酶转化为生物活性代谢物：5(6)-氧化-PGI1 。

Transformation of prostacyclin (PGI2) to a biologically active metabolite: 5(6)-oxido-PGI1 by cytochrome P450-dependent epoxygenase.

作者信息

Wong P Y

机构信息

Department of Physiology and Medicine, New York Medical College, Valhalla 10595.

出版信息

Adv Exp Med Biol. 1990;281:245-50. doi: 10.1007/978-1-4615-3806-6_24.

DOI:10.1007/978-1-4615-3806-6_24

PMID:2102615

Abstract

The renal epoxygenase has been demonstrated to be an active pathway for the conversion of PGI2 to a new, previously unreported, metabolite. This metabolite was isolated and identified by radiogas-chromatography-mass spectrometry as 5-hydroxy-6-keto PGF1 alpha. Its structure was further confirmed by comparison of the mass-spectra to that of the synthetic standard. The formation of 5-hydroxy-6-keto PGF1 alpha in the kidney suggested epoxidation of prostacyclin via the renal epoxygenase as an alternative pathway of PGI2 metabolism.

摘要

肾环氧合酶已被证明是将前列环素（PGI2）转化为一种新的、以前未报道过的代谢产物的活性途径。这种代谢产物通过放射性气相色谱 - 质谱法分离并鉴定为5 - 羟基 - 6 - 酮前列地尔F1α。通过将质谱与合成标准品的质谱进行比较，进一步证实了其结构。肾脏中5 - 羟基 - 6 - 酮前列地尔F1α的形成表明，通过肾环氧合酶使前列环素环氧化是前列环素（PGI2）代谢的另一条途径。