The effect of cyclophosphamide derivatives on cellular cytotoxicity (NK, ADCC) in vitro.
作者信息
Wasik M, Rychlik G, Górski A
机构信息
Department of Immunology, Transplantation Institute, Medical School, Warsaw.
出版信息
Arch Immunol Ther Exp (Warsz). 1990;38(3-4):259-65.
PMID:2102658
Abstract
We have studied the effect of alkylating agents (AA): cyclophosphamide (Cy), 4-hydroperoxycyclophosphamide (4HCy), mafosfamide (MF), and nitrogranulogen (NTG) on cytotoxicity evaluated in ADCC and NK assays. While NK cells were sensitive to AA, higher concentrations of 4HCy and MF were necessary to affect killer cells active in ADCC assay. NTG which was without any effect on ADCC was found to be the most efficacious inhibitor on NK activity.
摘要
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