环磷酰胺与胸腺刺激素联合治疗对小鼠脾细胞体外自然杀伤及杀念珠菌活性的影响。
Combined effects of cyclophosphamide and thymostimulin treatment on the in vitro natural killer and candidacidal activity of murine spleen cells.
作者信息
Baccarini M, Scaringi L, Puccetti P, Falchetti R, D'Errico P, Bistoni F
出版信息
Int J Tissue React. 1984;6(6):485-92.
PMID:6530352
Abstract
Two different natural cell-mediated cytotoxic reactions (lysis of YAC-1 and killing of Candida albicans) in vitro were studied in mice undergoing treatment with cyclophosphamide (Cy), thymostimulin (TP-1) or a combination of both. Enhancing effects followed the combination regime in the microbial natural cell-mediated cytotoxicity assay, whereas in the NK assay the effect of TP-1 appeared to be antagonistic to that of Cy. The possible mechanisms involved are discussed.
摘要
在接受环磷酰胺（Cy）、胸腺刺激素（TP - 1）或两者联合治疗的小鼠中，研究了两种不同的体外自然细胞介导的细胞毒性反应（YAC - 1细胞裂解和白色念珠菌杀伤）。在微生物自然细胞介导的细胞毒性试验中，联合用药方案具有增强作用，而在自然杀伤（NK）试验中，TP - 1的作用似乎与Cy拮抗。文中讨论了其中可能涉及的机制。
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