Kim Han Sang, Pak Hui-Nam, Park Jong Seoung, Kim Sung Soon
Yonsei University Health System, Seoul, Republic of Korea.
Pacing Clin Electrophysiol. 2013 Mar;36(3):e84-6. doi: 10.1111/j.1540-8159.2010.02935.x. Epub 2010 Oct 28.
Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia. We present a patient who experienced recurrent syncope due to bradycardia-dependent torsade de pointes (TdP) associated with flecainide-related bradycardia and QT prolongation. Bradycardia-dependent TdP with QT prolongation can be considered as one of mechanisms of flecainide-induced proarrhythmia.
尽管氟卡尼在有结构性心脏病的患者中有促心律失常的风险，但其机制主要归因于使用依赖性以及对有组织的房性快速心律失常或室性心动过速的快速心室反应。我们报告了一名患者，该患者因与氟卡尼相关的心动过缓和QT延长相关的心动过缓依赖性尖端扭转型室性心动过速（TdP）而反复出现晕厥。伴有QT延长的心动过缓依赖性TdP可被视为氟卡尼诱发心律失常的机制之一。
