Department of Oral Rehabilitation, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
Oral Dis. 2011 Apr;17(3):335-9. doi: 10.1111/j.1601-0825.2010.01762.x. Epub 2010 Oct 28.
To present a combination of clinical and histopathological criteria for diagnosing cheilitis glandularis (CG), and to evaluate the association between CG and squamous cell carcinoma (SCC).
The medical literature in English was searched from 1950 to 2010 and selected demographic data, and clinical and histopathological features of CG were retrieved and analysed.
A total of 77 cases have been published and four new cases were added to the collective data. The clinical criteria applied included the coexistence of multiple lesions and mucoid/purulent discharge, while the histopathological criteria included two or more of the following findings: sialectasia, chronic inflammation, mucous/oncocytic metaplasia and mucin in ducts. Only 47 (58.0%) cases involving patients with a mean age of 48.5 ± 20.3 years and a male-to-female ratio of 2.9:1 fulfilled the criteria. The lower lip alone was most commonly affected (70.2%). CG was associated with SCC in only three cases (3.5%) for which there was a clear aetiological factor for the malignancy.
The proposed diagnostic criteria can assist in delineating true CG from a variety of lesions with a comparable clinical/histopathological presentation. CG in association with premalignant/malignant epithelial changes of the lower lip may represent secondary, reactive changes of the salivary glands.
提出联合临床和组织病理学标准来诊断唇腺炎，并评估唇腺炎与鳞状细胞癌（SCC）之间的关联。
检索了 1950 年至 2010 年的英文医学文献，并检索和分析了唇腺炎的人口统计学数据、临床和组织病理学特征。
共发表了 77 例病例，在汇总数据中又增加了 4 例新病例。应用的临床标准包括多个病变的共存和黏液脓性分泌物，而组织病理学标准包括以下两个或更多发现：唾液腺扩张、慢性炎症、黏液/嗜酸性细胞化生和导管中的粘蛋白。仅有 47 例（58.0%）符合标准，涉及的患者平均年龄为 48.5 ± 20.3 岁，男女比例为 2.9:1。最常见的病变部位是下唇（70.2%）。唇腺炎与 SCC 仅在 3 例中相关（3.5%），这些病例存在恶性肿瘤的明确病因。
所提出的诊断标准可有助于将真正的唇腺炎与具有相似临床/组织病理学表现的各种病变区分开来。下唇的唇腺炎伴癌前/恶性上皮改变可能代表唾液腺的继发性、反应性变化。
