Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.
J Am Acad Dermatol. 2010 Feb;62(2):233-8. doi: 10.1016/j.jaad.2009.06.038. Epub 2009 Dec 11.
Cheilitis glandularis (CG) is a condition in which thick saliva is secreted by minor labial salivary glands and adheres to a swollen lip causing discomfort to the patient. Most publications refer to single case reports or small case series.
We sought to report and to analyze clinical, pathological, and therapeutic data on 22 patients with CG seen at the department of dermatology at our university.
Retrospective data about 22 patients with CG are reviewed and presented.
Seventeen patients were male and 5 were female. All were fair skinned, including 6 albino individuals. Several of them presented significant signs of photodamage on the lips. Surgical treatment was performed in 10 severely affected patients and consisted of a vermilionectomy followed by minor salivary gland removal. Histopathological study revealed various degrees of chronic sialadenitis and vermilion epithelial changes. Superficially invasive and in situ squamous cell carcinoma of the vermilion was detected in 3 cases.
Biopsy and surgery were not performed in all patients.
CG is strongly related to sun sensitivity and may be more severe in albino patients. The swollen, sun-exposed lip may become more susceptible to the occurrence of squamous cell carcinoma.
唇腺炎（CG）是一种小唇唾液腺分泌大量唾液并附着在肿胀的嘴唇上，导致患者不适的病症。大多数出版物都提到了单一病例报告或小病例系列。
我们旨在报告并分析在我们大学皮肤科就诊的 22 例 CG 患者的临床、病理和治疗数据。
回顾性分析 22 例 CG 患者的资料并进行呈现。
17 例为男性，5 例为女性。所有患者肤色白皙，包括 6 名白化病患者。其中一些人嘴唇上有明显的光损伤迹象。10 例病情严重的患者接受了手术治疗，包括唇红切除术和小唾液腺切除术。组织病理学研究显示不同程度的慢性唾液腺炎和唇红上皮变化。3 例检测到唇红浅表浸润性和原位鳞状细胞癌。
并非所有患者都进行了活检和手术。
CG 与阳光敏感强烈相关，在白化病患者中可能更为严重。肿胀的、暴露在阳光下的嘴唇更容易发生鳞状细胞癌。
