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2
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本文引用的文献

1
Burden of malaria during pregnancy at the time of IPTp/SP implementation in Gabon.冈比亚在实施 IPTp/SP 时孕期疟疾负担。
Am J Trop Med Hyg. 2010 Feb;82(2):202-9. doi: 10.4269/ajtmh.2010.09-0267.
2
High prevalence of sulfadoxine/pyrimethamine-resistant alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrimethamine in Gabon.在加蓬引入磺胺多辛/乙胺嘧啶间歇性预防治疗时，孕妇中疟原虫分离株磺胺多辛/乙胺嘧啶耐药等位基因的高流行率。
J Antimicrob Chemother. 2010 Mar;65(3):438-41. doi: 10.1093/jac/dkp467. Epub 2010 Jan 6.
3
Molecular correlates of high-level antifolate resistance in Rwandan children with Plasmodium falciparum malaria.卢旺达儿童恶性疟原虫感染中高水平抗叶酸耐药的分子相关性。
Antimicrob Agents Chemother. 2010 Jan;54(1):477-83. doi: 10.1128/AAC.00498-09. Epub 2009 Oct 19.
4
Plasmodium falciparum malaria in pregnancy: prevalence of peripheral parasitaemia, anaemia and malaria care-seeking behaviour among pregnant women attending two antenatal clinics in Edo State, Nigeria.妊娠期间的恶性疟原虫疟疾：尼日利亚江户州两家产前诊所就诊孕妇的外周血寄生虫血症患病率、贫血情况及疟疾就医行为
J Obstet Gynaecol. 2009 May;29(4):301-6. doi: 10.1080/01443610902883320.
5
Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine.贝宁孕期疟疾预防的间歇性治疗：一项比较磺胺多辛-乙胺嘧啶与甲氟喹的随机、开放标签等效性试验。
J Infect Dis. 2009 Sep 15;200(6):991-1001. doi: 10.1086/605474.
6
Pregnancy-associated malaria in a rural community of ghana.加纳一个农村社区的妊娠相关疟疾
Ghana Med J. 2009 Mar;43(1):13-8.
7
Comparison of sulfadoxine-pyrimethamine, unsupervised artemether-lumefantrine, and unsupervised artesunate-amodiaquine fixed-dose formulation for uncomplicated plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial.磺胺多辛-乙胺嘧啶、无监督使用的蒿甲醚-本芴醇以及无监督使用的青蒿琥酯-阿莫地喹固定剂量复方制剂用于贝宁单纯性恶性疟的比较：一项随机有效性非劣效性试验
J Infect Dis. 2009 Jul 1;200(1):57-65. doi: 10.1086/599378.
8
Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in pregnant women who receive preventive treatment.在接受预防性治疗的孕妇中，耐药恶性疟原虫疟疾寄生虫的竞争性促进作用。
Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9027-32. doi: 10.1073/pnas.0901415106. Epub 2009 May 18.
9
Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania.青蒿琥酯+阿莫地喹、磺胺多辛-乙胺嘧啶+阿莫地喹、氯胍-氨苯砜及磺胺多辛-乙胺嘧啶用于坦桑尼亚孕期疟疾治疗的随机试验
PLoS One. 2009;4(4):e5138. doi: 10.1371/journal.pone.0005138. Epub 2009 Apr 8.
10
High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581.坦桑尼亚北部恶性疟原虫对周效磺胺/乙胺嘧啶的高抗性以及第581位密码子二氢蝶酸合酶（DHPS）抗性突变的出现。
PLoS One. 2009;4(2):e4569. doi: 10.1371/journal.pone.0004569. Epub 2009 Feb 24.

磺胺多辛/乙胺嘧啶间歇性预防治疗妊娠疟疾。

Sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy.

机构信息

Institut de Recherche pour le Developpement, Paris, France.

出版信息

Emerg Infect Dis. 2010 Nov;16(11):1666-70. doi: 10.3201/eid1611.101064.

DOI:10.3201/eid1611.101064
PMID:21029522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3294539/
Abstract

For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase and dihydrofolate reductase genes of Plasmodium falciparum parasites contrasts with the efficacy of sulfadoxine/pyrimethamine in reducing low birthweights and placental infection rates. In light of this discrepancy, emphasis on using molecular markers for monitoring efficacy of intermittent preventive treatment during pregnancy appears questionable. The World Health Organization recently proposed conducting in vivo studies in pregnant women to evaluate molecular markers for detecting resistance precociously. Other possible alternative strategies are considered.

摘要

为了监测妊娠期间使用磺胺多辛/乙胺嘧啶间歇性预防治疗疟疾的效果，从儿童研究中获得的数据似乎不够充分。恶性疟原虫二氢叶酸合成酶和二氢叶酸还原酶基因中的三重和四重突变体的高流行率与磺胺多辛/乙胺嘧啶降低低出生体重和胎盘感染率的效果形成对比。鉴于这种差异，强调使用分子标记物来监测妊娠期间间歇性预防治疗的效果似乎值得怀疑。世界卫生组织最近提议在孕妇中进行体内研究，以评估用于早期检测耐药性的分子标记物。还考虑了其他可能的替代策略。