Chen Xing-shi, Tang Yun-xiang, Xu Yi-feng, Xiao Ze-ping, Wang Ji-jun, Zhang Ming-dao, Lou Fei-ying, Chen Chong
Department of Electrophysiology, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai 200030, China.
Zhonghua Yi Xue Za Zhi. 2010 Aug 3;90(29):2026-9.
To explore N400 changes elicited by Chinese sentences ending with matching (congruent) or mismatching (incongruent) words in first episode schizophrenia.
ERP (event-related potentials) component N400 were recorded by an ERP device in 56 first episode schizophrenia (FES) and 62 normal controls (NC) according to a paradigm of Chinese sentences ending with matching or mismatching words.
(1) Latencies: compared with NC, FES showed prolonged N400 latencies in five areas at pre-treatment: in Cz. The latencies were (358 ms ± 32 ms vs 394 ms ± 45 ms, P < 0.01) in congruent and (410 ms ± 29 ms vs 446 ms ± 35 ms, P < 0.01) in incongruent situation. And so did in Fz, Pz, C3 and C4; (2) amplitudes: compared with NC, FES also showed smaller N400 amplitudes in five areas at pre-treatment. The amplitudes were (8.6 µV ± 5.1 µV vs 5.2 µV ± 4.6 µV, P < 0.01) in congruent and (13.4 µV ± 6.7 µV vs 8.5 µV ± 5.9 µV, P < 0.01) in incongruent situation. And so did in Fz, Pz, C3 and C4; (3) the prolonged N400 latencies and decreased amplitudes were negatively correlated with the patients' positive scale and total scale of PANSS.
With clear priming effect in first episode schizophrenia, Chinese sentences are suitable stimuli in N400 experiment. They may be used for further study of neural mechanism and early diagnosis of schizophrenia.
探讨首发精神分裂症患者对以匹配（一致）或不匹配（不一致）词语结尾的中文句子所引发的N400变化。
采用以匹配或不匹配词语结尾的中文句子范式，通过事件相关电位（ERP）设备记录56例首发精神分裂症（FES）患者和62名正常对照（NC）的ERP成分N400。
（1）潜伏期：与NC相比，FES患者治疗前在五个区域的N400潜伏期延长。在Cz区域，一致情况下潜伏期为（358毫秒±32毫秒对394毫秒±45毫秒，P<0.01），不一致情况下为（410毫秒±29毫秒对446毫秒±35毫秒，P<0.01）。Fz、Pz、C3和C4区域也是如此；（2）波幅：与NC相比，FES患者治疗前在五个区域的N400波幅也较小。一致情况下波幅为（8.6微伏±5.1微伏对5.2微伏±4.6微伏，P<0.01），不一致情况下为（13.4微伏±6.7微伏对8.5微伏±5.9微伏，P<0.01）。Fz、Pz、C3和C4区域也是如此；（3）N400潜伏期延长和波幅降低与患者的阳性量表及PANSS总分呈负相关。
首发精神分裂症患者具有明确的启动效应，中文句子是N400实验的合适刺激。它们可用于进一步研究精神分裂症的神经机制和早期诊断。
