非典型支原体和衣原体感染对哮喘的影响。
Effects of atypical infections with Mycoplasma and Chlamydia on asthma.
机构信息
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, 4309 Medical Park Drive, Durham, NC 27704, USA.
出版信息
Immunol Allergy Clin North Am. 2010 Nov;30(4):575-85, vii-viii. doi: 10.1016/j.iac.2010.08.003. Epub 2010 Sep 22.
Abstract
Mycoplasma pneumoniae and Chlamydophila pneumoniae are atypical bacteria that are frequently found in patients with asthma. A definitive diagnosis of infection is often difficult to obtain because of limitations with sampling and detection. Numerous animal studies have outlined mechanisms by which these infections may promote allergic lung inflammation and airway remodeling. In addition, there is mounting evidence from human studies suggesting that atypical bacterial infections contribute to asthma exacerbations, chronic asthma, and disease severity. The role of antimicrobials directed against atypical bacteria in asthma is still under investigation.
摘要
肺炎支原体和肺炎衣原体是常见于哮喘患者的非典型细菌。由于采样和检测的限制，通常难以明确诊断感染。许多动物研究已经概述了这些感染可能促进过敏性肺炎症和气道重塑的机制。此外，越来越多的来自人类研究的证据表明，非典型细菌感染会导致哮喘恶化、慢性哮喘和疾病严重程度增加。针对非典型细菌的抗生素在哮喘中的作用仍在研究中。
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Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells.阿奇霉素、克拉霉素和泰利霉素抑制肺炎衣原体诱导气道上皮细胞 MUC5AC 的表达。
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