Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland.
Immunity. 2010 Oct 29;33(4):451-63. doi: 10.1016/j.immuni.2010.10.008.
Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease. Recently, new methods have been developed to dissect the immune response in experimental animals and humans, which have led to increased understanding of the molecular mechanisms that control differentiation and maintenance of memory T and B cells. In this review we will provide an overview of the cellular organization of immune memory and underline some of the outstanding questions on immunological memory and how they pertain to vaccination strategies. Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells-a journey from vaccines to memory and back.
疫苗通过引发免疫反应和随之产生的免疫记忆来介导对感染或疾病的保护。最近，已经开发出了新的方法来剖析实验动物和人类的免疫反应，这使得人们对控制记忆 T 和 B 细胞分化和维持的分子机制有了更多的了解。在这篇综述中，我们将概述免疫记忆的细胞组织，并强调一些关于免疫记忆的悬而未决的问题，以及它们与疫苗接种策略的关系。最后，我们将讨论我们如何从记忆 T 和 B 细胞的检测中了解抗原设计——从疫苗到记忆，再回到疫苗。
