年龄和初次疫苗接种程序对使用灭活新冠病毒疫苗后的体液免疫和细胞免疫有影响。
Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine.
作者信息
Martínez-Balboa Yohana, Rodríguez-Guilarte Linmar, Méndez Constanza, Ríos Mariana, Rivera Daniela B, Moreno-Tapia Daniela, Reyes Humberto A, Pereira-Sánchez Patricia, Orellana Claudia, Cabrera Alex, Schultz Bárbara M, Duarte Luisa F, Gálvez Nicolás M S, Melo-González Felipe, Soto Jorge A, Iturriaga Carolina, Urzúa Marcela, Navarrete María S, Rojas Álvaro, Fasce Rodrigo A, Fernández Jorge, Mora Judith, Ramírez Eugenio, Weiskopf Daniela, Grifoni Alba, Sette Alessandro, Zeng Gang, Meng Weining, Alvarez-Figueroa María Javiera, González-Aramundiz José V, Domínguez M Angélica, González Pablo A, Abarca Katia, Peñaloza Hernán F, Bueno Susan M, Kalergis Alexis M
机构信息
Millennium Institute on Immunology and Immunotherapy, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Flow Cytometry Facility, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
出版信息
iScience. 2025 Jul 21;28(8):113167. doi: 10.1016/j.isci.2025.113167. eCollection 2025 Aug 15.
Despite widespread COVID-19 vaccination, questions remain about vaccine safety and immunogenicity in vulnerable populations, such as older adults. We evaluated the safety and immunogenicity of four doses of CoronaVac in adults above and below 60 who received the first two doses in two different schedules (0-14 and 0-28 days apart). While CoronaVac demonstrated excellent safety across age groups, older adults showed reduced reactogenicity. In the 0-28 schedule, both age groups exhibited similar frequencies of SARS-CoV-2-specific CD4 and CD8 T cells, though memory T cell distribution patterns differed. Notably, adults over 60 showed diminished virus-neutralizing antibody responses compared to younger participants. The 0-14 schedule produced equivalent cellular and neutralizing antibody responses between age groups, albeit at lower levels than the 0-28 schedule. Our data indicate that primary vaccination schedules can influence the humoral immune responses and memory T cell distribution between age groups.
尽管新冠疫苗已广泛接种，但对于老年人等弱势群体的疫苗安全性和免疫原性仍存在疑问。我们评估了四剂科兴疫苗在60岁及以上和60岁以下成年人中的安全性和免疫原性，这些成年人按照两种不同的接种程序（间隔0-14天和0-28天）接种了前两剂疫苗。虽然科兴疫苗在各年龄组中均显示出良好的安全性，但老年人的反应原性较低。在0-28天的接种程序中，两个年龄组的SARS-CoV-2特异性CD4和CD8 T细胞频率相似，尽管记忆T细胞分布模式有所不同。值得注意的是，与年轻参与者相比，60岁以上的成年人病毒中和抗体反应减弱。0-14天的接种程序在各年龄组之间产生了相当的细胞和中和抗体反应，尽管水平低于0-28天的接种程序。我们的数据表明，初次接种程序可影响各年龄组之间的体液免疫反应和记忆T细胞分布。
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