Division of Immunology, The Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia.
Immunity. 2010 Oct 29;33(4):555-66. doi: 10.1016/j.immuni.2010.10.005.
The concept of a malaria vaccine has sparked great interest for decades; however, the challenge is proving to be a difficult one. Immune dysregulation by Plasmodium and the ability of the parasite to mutate critical epitopes in surface antigens have proved to be strong defense weapons. This has led to reconsideration of polyvalent and whole parasite strategies and ways to enhance cellular immunity to malaria that may be more likely to target conserved antigens and an expanded repertoire of antigens. These and other concepts will be discussed in this review.
疟疾疫苗的概念几十年来一直引起人们的极大兴趣；然而，事实证明这是一个艰巨的挑战。疟原虫的免疫失调和寄生虫突变表面抗原关键表位的能力已被证明是强大的防御武器。这导致人们重新考虑多价和全寄生虫策略，并寻找增强疟疾细胞免疫的方法，这可能更有可能针对保守抗原和扩大的抗原谱。在这篇综述中，将讨论这些和其他概念。
