Noussi Djouwoug Clarice, Ngueguim Florence Tsofack, Kamkumo Gounoue Raceline, Donfack Gouni Clémence, Kandeda Antoine Kavaye, Philippe Djientcheu Jean, Fifen Rodrigue, Djomeni Dzeufiet Desire Paul, Ngouela Silvère, Sewald Norbert, Lenta Bruno Ndjakou, Dimo Theophile
Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Evid Based Complement Alternat Med. 2020 Nov 25;2020:3160834. doi: 10.1155/2020/3160834. eCollection 2020.
) is a plant used in Cameroonian traditional medicine to manage diabetes. The effects of hydroethanolic barks extract from were evaluated on diabetes disorders including hematology, inflammatory, and oxidative stress parameters. The in vitro antioxidant capacity of the hydroethanolic bark extract (70 : 30) was evaluated. Nicotinamide-/streptozotocin-induced diabetic rats were daily treated with the extract for fifteen days. Glycemia were evaluated every 5 days, insulin sensibility test was performed, and haematological, inflammatory, and oxidative stress parameters were analysed. Histomorphometry of the pancreas was realized. The extract was able to scavenge free radicals in vitro and decrease significantly the blood glucose levels. The treatment resulted in a significant alleviation of insulin resistance, anemia, leukocytopenia, and thrombocytopenia observed in untreated diabetic rats. The extract significantly decreased proinflammatory cytokines TNF-, IL-1, and IL-10. The rate of reduced glutathione was increased in the pancreas, whereas the catalase activity and nitrite concentration were decreased. Diabetic control showed a reduced size of Langerhans islet, whereas the size of islets was large in treated groups. The hydroethanolic extract of was able to improve glycemia and alleviate haematological and inflammatory parameters disorders observed in diabetic conditions, probably due to its antidiabetic, anti-inflammatory, and antioxidant capacities.
)是喀麦隆传统医学中用于治疗糖尿病的一种植物。对[植物名称]树皮的水乙醇提取物对糖尿病相关病症（包括血液学、炎症和氧化应激参数）的影响进行了评估。评估了水乙醇树皮提取物（70 : 30）的体外抗氧化能力。用烟酰胺/链脲佐菌素诱导糖尿病大鼠，每天用[植物名称]提取物治疗15天。每5天评估血糖水平，进行胰岛素敏感性测试，并分析血液学、炎症和氧化应激参数。对胰腺进行组织形态计量学分析。该提取物能够在体外清除自由基并显著降低血糖水平。治疗导致未治疗的糖尿病大鼠中观察到的胰岛素抵抗、贫血、白细胞减少和血小板减少得到显著缓解。该提取物显著降低促炎细胞因子TNF-、IL-1和IL-10。胰腺中还原型谷胱甘肽的比率增加，而过氧化氢酶活性和亚硝酸盐浓度降低。糖尿病对照组显示胰岛大小减小，而治疗组的胰岛较大。[植物名称]的水乙醇提取物能够改善血糖水平，并缓解糖尿病状态下观察到的血液学和炎症参数紊乱，这可能归因于其抗糖尿病、抗炎和抗氧化能力。
