回收内体和 TLR 信号转导——Rab11 GTP 酶引领前路。
Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way.
机构信息
Department of Pediatrics, Division of Gastroenterology and Harvard Medical School, Children's Hospital Boston, 300 Longwood Ave, Enders 730.2, Boston, MA 02115, USA.
出版信息
Immunity. 2010 Oct 29;33(4):578-80. doi: 10.1016/j.immuni.2010.10.003.
PMID:21029967
Abstract
The ability of Toll-like receptors (TLRs) to activate innate immunity depends on their transport to pathogen-containing organelles. In this issue of Immunity, Husebye et al. (2010) report that delivery of TLR4 to phagosomes occurs via a recycling endosome intermediate, which is controlled by the GTPase Rab11a.
摘要
Toll 样受体（TLRs）激活先天免疫的能力依赖于它们向包含病原体的细胞器的运输。在本期《免疫》中，Husebye 等人（2010）报道 TLR4 通过一个再循环内体中间物被递送到吞噬体，该中间物受 GTP 酶 Rab11a 的控制。
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