一名献血者及其家族中抗-PP1P(k)的鉴定：妊娠后的病例报告及文献复习

Identification of anti-PP1P(k) in a blood donor and her family: a case report following her pregnancy and review.

作者信息

Benidt Georgette R, Jaben Elizabeth A, Winters Jeffrey L, Stubbs James R

机构信息

Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA.

出版信息

Transfus Apher Sci. 2010 Dec;43(3):369-374. doi: 10.1016/j.transci.2010.10.009. Epub 2010 Oct 27.

DOI:10.1016/j.transci.2010.10.009

PMID:21030308

Abstract

Anti-PP1P(k) is a rare, biphasic antibody with the ability to cause immediate hemolytic transfusion reactions and early spontaneous abortions. The antibody is formed by individuals with the p phenotype. A blood donor with anti-PP1P(k) and the p phenotype was identified through routine donor screening. A sister was found to also be p phenotype. At that time, the sister was 24weeks pregnant. Subsequently, the original blood donor became pregnant. Both individuals were followed throughout their pregnancies and delivered infants without complications from anti-PP1P(k) antibodies. The literature regarding anti-PP1P(k), the p phenotype, and recurrent pregnancy loss in this setting is reviewed.

摘要

抗-PP1P(k)是一种罕见的双相抗体，能够引发即刻溶血性输血反应和早期自然流产。该抗体由具有p血型表型的个体产生。通过常规献血者筛查，发现了一名携带抗-PP1P(k)且为p血型表型的献血者。还发现其一名姐妹同样为p血型表型。当时，该姐妹已怀孕24周。随后，最初的献血者也怀孕了。在她们整个孕期都进行了跟踪，两人分娩的婴儿均未出现抗-PP1P(k)抗体引发的并发症。本文对有关抗-PP1P(k)、p血型表型以及在此情况下复发性流产的文献进行了综述。