Children's National Medical Center, Division of Emergency Medicine, Center for Clinical and Community Research, Washington, District of Columbia, USA.
Curr Opin Endocrinol Diabetes Obes. 2010 Dec;17(6):530-4. doi: 10.1097/MED.0b013e32833e9c8b.
Summary highlighting the evidence that bone health may affect forearm fracture risk in children.
Although the incidence of other fractures and injuries are decreasing, the incidence of forearm fractures is increasing in otherwise healthy children. There is a growing volume of research that forearm fracture risk in children may be related to deficiencies in parameters of bone health. Available evidence of this relationship was summarized and included direct links to bone health (measurement of bone properties), indirect links to bone health (diet, vitamin D status, BMI), and genetic analyses.
There is consistent and convincing evidence of an association between bone mineral density and forearm fracture risk in children. Studies of calcium intake and supplementation are less extensive in scope but suggest that effects of calcium deficiency on the radius may contribute to childhood forearm fracture risk. Forearm fracture risk in obese children is likely to reflect a combination of suboptimal bone health status and behavioral characteristics. Published data on the role of vitamin D status and genetic factors are limited but merit further consideration. Further investigation is needed to better understand the factors contributing to forearm fracture risk in children and translate this knowledge into effective clinical prevention and practice.
强调骨健康可能影响儿童前臂骨折风险的证据。
尽管其他骨折和损伤的发生率正在下降,但在其他方面健康的儿童中,前臂骨折的发生率正在上升。越来越多的研究表明,儿童前臂骨折的风险可能与骨健康参数的不足有关。总结了该关系的现有证据,包括与骨健康的直接联系(骨特性的测量)、与骨健康的间接联系(饮食、维生素 D 状况、BMI)和遗传分析。
有一致且令人信服的证据表明骨密度与儿童前臂骨折风险之间存在关联。钙摄入量和补充的研究范围较小,但表明钙缺乏对桡骨的影响可能导致儿童前臂骨折风险增加。肥胖儿童的前臂骨折风险可能反映了骨健康状况不佳和行为特征的综合影响。关于维生素 D 状况和遗传因素作用的已发表数据有限,但值得进一步考虑。需要进一步研究以更好地了解导致儿童前臂骨折风险的因素,并将这些知识转化为有效的临床预防和实践。