骨髓脂肪组织：其在骨重塑和再生中的起源、功能及调控
Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration.
作者信息
Li Qiwen, Wu Yunshu, Kang Ning
机构信息
State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Stem Cells Int. 2018 May 31;2018:7098456. doi: 10.1155/2018/7098456. eCollection 2018.
Abstract
Marrow adipose tissue (MAT) is a unique fat depot in the bone marrow and exhibits close relationship with hematopoiesis and bone homeostasis. MAT is distinct from peripheral adipose tissue in respect of its heterogeneous origin, site-specific distribution, and complex and perplexing function. Though MAT is indicated to function in hematopoiesis, skeletal remodeling, and energy metabolism, its explicit characterization still requires further research. In this review, we highlight recent advancement made in MAT regarding the origin and distribution of MAT, the local interaction with bone homeostasis and hematopoietic niche, the systemic endocrine regulation of metabolism, and MAT-based strategies to enhance bone formation.
摘要
骨髓脂肪组织（MAT）是骨髓中一种独特的脂肪库，与造血和骨稳态密切相关。MAT在起源异质性、部位特异性分布以及复杂且令人费解的功能方面与外周脂肪组织不同。尽管MAT被认为在造血、骨骼重塑和能量代谢中发挥作用，但其确切特征仍需进一步研究。在本综述中，我们重点介绍了MAT在以下方面的最新进展：MAT的起源和分布、与骨稳态和造血微环境的局部相互作用、代谢的全身内分泌调节以及基于MAT的增强骨形成的策略。
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