Michael E. DeBakey Veterans Affairs Medical Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Am J Med Sci. 2011 Jan;341(1):78-82. doi: 10.1097/MAJ.0b013e3181f6c6ea.
Invasive disease caused by Candida spp. is being appreciated with increased frequency especially associated with widespread use of immunosuppressive drug therapy. We report a case of spinal osteomyelitis and epidural abscess caused by Candida glabrata occurring in a patient who had been diagnosed with candidemia 3 months before that patient was treated with fluconazole. The infection was successfully treated with amphotericin B, but the patient eventually required surgical intervention for spondylolisthesis with impingement on the cauda equina.
念珠菌属引起的侵袭性疾病的发病率正在不断增加,尤其是与广泛使用免疫抑制药物治疗有关。我们报告了一例由光滑念珠菌引起的脊髓骨炎和硬膜外脓肿的病例,该患者在被诊断为念珠菌血症 3 个月前曾接受氟康唑治疗。该感染经两性霉素 B 成功治疗,但患者最终因脊椎滑脱并对马尾神经造成压迫而需要手术干预。