Institute of Internal Medicine, Catholic University of Rome, Italy.
Eur J Gastroenterol Hepatol. 2011 Jan;23(1):76-80. doi: 10.1097/MEG.0b013e32834101f9.
Excessive alcohol consumption often results in intestinal damage, mediated by inflammatory processes, mainly characterized by an increased influx of leukocytes. Fecal calprotectin is a granulocyte cytosolic protein, representing as a promising marker of subclinical intestinal inflammation. In this study, we assessed fecal calprotectin concentrations (FCCs) in current drinking alcoholics, both at the baseline, and then during a subsequent 84-day period. Moreover, FCCs in the alcoholics were compared with the FCCs in healthy controls.
Twenty-eight, active-drinking alcoholics were enrolled in this study and compared with 40 healthy volunteers as the control group. In alcoholics, FCCs were determined at the beginning of the study (baseline; T0) and then every 2 weeks (T1-T6) during the following 84-day period. Potential differences in FCCs were analyzed between alcoholics and healthy controls, and during the 84-day period within the group of alcoholics. In addition, an analysis of FCCs was conducted in three subgroups of alcoholics, considering their drinking status during the 84-day period (abstinent, relapsed, and active).
At baseline, no significant differences in median FCCs were found between alcoholics and controls. No significant changes of median FCCs were found, comparing baseline FCCs and FCCs during the 84-day period (T1-T6) in the whole group of alcoholics, nor in the three subgroups of alcoholics.
FCCs in active-drinking alcoholics are not significantly different, compared with the healthy controls. Moreover, FCCs do not significantly differ according to the alcohol drinking status. These results may suggest the absence of a subclinal intestinal inflammation involving neutrophils in the alcoholics.
过量饮酒常导致肠道损伤，这一过程主要通过炎症反应介导，其特征主要为白细胞的过度涌入。粪便钙卫蛋白是一种粒细胞胞质蛋白，是一种有前途的亚临床肠道炎症标志物。在本研究中，我们评估了当前饮酒酗酒者的粪便钙卫蛋白浓度（FCCs），并在随后的 84 天期间进行了评估。此外，我们还将酗酒者的 FCCs 与健康对照组的 FCCs 进行了比较。
本研究共纳入 28 名活跃饮酒的酗酒者，并与 40 名健康志愿者作为对照组进行比较。在酗酒者中，FCCs 在研究开始时（基线；T0）确定，然后在接下来的 84 天期间每两周（T1-T6）确定一次。分析了酗酒者与健康对照组之间以及酗酒者组内 84 天期间 FCCs 的潜在差异。此外，还对考虑到 84 天期间酗酒者饮酒状况的三个亚组的 FCCs 进行了分析（禁欲、复发和活跃）。
基线时，酗酒者和对照组的 FCCs 中位数无显著差异。在整个酗酒者组以及三个酗酒者亚组中，基线 FCCs 与 84 天期间的 FCCs（T1-T6）之间的 FCCs 中位数均未发生显著变化。
与健康对照组相比，活跃饮酒的酗酒者的 FCCs 没有显著差异。此外，根据饮酒状况，FCCs 也没有显著差异。这些结果可能表明，酗酒者不存在涉及中性粒细胞的亚临床肠道炎症。
