Soria F, Alegría E, Valdés M, García A, Vicente T, Castello M J
Departamento de Cardiología y Cirugía Cardiovascular, Clínica Universitaria de Navarra.
An Med Interna. 1990 Nov;7(11):565-9.
42 mild and moderate hypertensive patients treated with Verapamil, Atenolol and Xipamide were studied. Exercise tests (ET) were performed at the onset and after a month of therapy, in order to detect arrhythmias and repolarization change prevalence of ventricular arrhythmias (VA) was 23.7% and 11.9% for supraventricular arrhythmias (SVA). 45.2% of the exercise tests were considered positive, with a significant correlation with maximum pressure peak. Patients with left ventricular hypertrophy (LVH) showed a significant increase in VA and +ET prevalence (42.1% and 63.2%). After treatment, the prevalence for VA registered a slight decrease and an increase for SVA; these differences not being considered significant. +ET showed a significant decrease in all patients, as well as in those with previous LVH (21.4%, 26.3%). Only atenolol produced a significant decrease in the +ET of patients with previous LVH (75% to 12.5%).
对42例接受维拉帕米、阿替洛尔和氯噻嗪治疗的轻度和中度高血压患者进行了研究。在治疗开始时和治疗一个月后进行运动试验(ET),以检测心律失常和复极变化。室性心律失常(VA)的患病率为23.7%,室上性心律失常(SVA)的患病率为11.9%。45.2%的运动试验被认为是阳性的,与最大压力峰值有显著相关性。左心室肥厚(LVH)患者的VA和+ET患病率显著增加(分别为42.1%和63.2%)。治疗后,VA患病率略有下降,SVA患病率有所上升;这些差异不被认为具有显著性。+ET在所有患者以及既往有LVH的患者中均显著下降(分别为21.4%、26.3%)。只有阿替洛尔使既往有LVH患者的+ET显著下降(从75%降至12.5%)。