Soria F, Alegría E, Valdés M, García A, Vicente T, Apellaniz G
Servicio de Cardiología, Clínica Universitaria de Navarra, Pamplona.
Rev Esp Cardiol. 1991 Jun-Jul;44(6):389-94.
With the objective of trying to prove the regression of ventricular mass in patients with essential hypertension, with and without left ventricular hypertrophy (LVH), we studied 42 patients of both sexes with echocardiography, measuring the left ventricular mass (LVM), the mean parietal thickness (MPT) and the relative parietal thickness (RPT), before and after one month of random treatment with atenolol, verapamil and xipamide, independently that the blood pressure control was or not satisfactory. We found significant reductions in the MPT with verapamil and atenolol (p = 0.006 and 0.036), although only verapamil induced a significant reduction of the LVM. The RPT did not shown any significant modification, although the tendency was opposed with xipamide and the other two groups, verapamil and atenolol. The factor Adequate control of the blood pressure, with any of the treatments, proved to be helpful in the favorable evolution of the regression. The degree of LVH before treatment does not appear to have any influence in the posterior evolution with the treatment.
为了试图证明原发性高血压患者无论有无左心室肥厚(LVH)时心室质量的消退情况,我们对42例男女患者进行了超声心动图研究,在使用阿替洛尔、维拉帕米和氯噻嗪随机治疗一个月前后,测量左心室质量(LVM)、平均室壁厚度(MPT)和相对室壁厚度(RPT),而不考虑血压控制是否令人满意。我们发现维拉帕米和阿替洛尔使MPT显著降低(p = 0.006和0.036),尽管只有维拉帕米使LVM显著降低。RPT没有显示出任何显著变化,尽管氯噻嗪与其他两组(维拉帕米和阿替洛尔)的变化趋势相反。事实证明,使用任何一种治疗方法充分控制血压,都有助于病情朝着消退的方向良好发展。治疗前LVH的程度似乎对治疗后的病情发展没有任何影响。