Mandelbaum I, Williams S D, Hornback N B, Joe B T, Einhorn L H
J Thorac Cardiovasc Surg. 1978 Sep;76(3):292-6.
Fifty-eight patients with small cell lung cancer were treated from September, 1974, to March, 1976, with combined chemotherapy and radiotherapy. Surgical resection of the lung lesion was performed in three patients, and a number of surgical diagnostic methods were carried out in the remaining patients with unresectable of disseminated lesions. Nineteen patients were from the Veterans Administration Hospital and 39 from Indiana University Medical Center. The median Karnofsky performance status was 60. Thirty-nine patients had extensive disease, and 19 had disease limited to the chest and supraclavicular area. All patients received chest radiotherapy and prophylactic whole brain radiation. Adriamycin, cyclophosphamide, and vincristine were given on day 1 and continued every 3 weeks. There were 27 (48 percent) partial remissions of a median duration of 26 weeks. There were 25 patients (43 percent) with complete remission. The median survival for the entire group was 51 weeks. Six of 58 patients (10 percent) are alive and disease free from 24 to 38 months after treatment. Six of 19 patients with limited disease (32 percent) are presently alive and disease free. This includes one patient in whom surgical resection was performed. Combined therapy influences favorably the prognosis of small cell cancer of the ling, expecially in those patients with limited disease and favorable performance status.
1974年9月至1976年3月，58例小细胞肺癌患者接受了化疗和放疗联合治疗。3例患者进行了肺部病变的手术切除，其余无法切除或有播散性病变的患者采用了多种手术诊断方法。19例患者来自退伍军人管理局医院，39例来自印第安纳大学医学中心。卡诺夫斯基功能状态中位数为60。39例患者有广泛病变，19例患者病变局限于胸部和锁骨上区域。所有患者均接受胸部放疗和预防性全脑放疗。阿霉素、环磷酰胺和长春新碱于第1天给药，每3周持续给药一次。有27例（48%）部分缓解，中位持续时间为26周。有25例患者（43%）完全缓解。整个组的中位生存期为51周。58例患者中有6例（10%）在治疗后24至38个月存活且无疾病。19例局限性疾病患者中有6例（32%）目前存活且无疾病。这包括1例接受了手术切除的患者。联合治疗对小细胞肺癌的预后有积极影响，尤其是对那些局限性疾病且功能状态良好的患者。
