乙肝表面抗原清除与乙肝病毒感染途径的相关性

Correlation of hepatitis B surface antigen clearance with the route of hepatitis B virus infection.

作者信息

Tassopoulos N C, Papaevangelou G J

机构信息

Department of Medicine, Western Attica General Hospital, Athens, Greece.

出版信息

J Gastroenterol Hepatol. 1990 May-Jun;5(3):252-5. doi: 10.1111/j.1440-1746.1990.tb01625.x.

DOI:10.1111/j.1440-1746.1990.tb01625.x

PMID:2103406

Abstract

We studied 563 consecutive adults with acute hepatitis B hospitalized from May 1981 to May 1983 and their habitual heterosexual partners. Radio-immunoassays for the detection of serological markers of hepatitis A virus (HAV) and hepatitis B virus (HBV) and enzyme-immunoassay for the detection of IgM antibody to hepatitis B core antigen (IgM anti-HBc) were used. Of the 563 patients, 503 (89.7%) were hepatitis B surface antigen (HBsAg) positive and 60 (10.7%) were HBsAg negative on admission. Absence of HBsAg on admission was observed significantly more frequently in patients infected possibly by the heterosexual route than in the remaining patients (23.3% versus 6.6%; P less than 0.001). This finding was independent of sex. These data show that the route of HBV infection rather than the sex appears to have a more important role in the rapid clearance of HBsAg.

摘要

我们研究了1981年5月至1983年5月期间连续收治的563例急性乙型肝炎成年患者及其固定的异性伴侣。采用放射免疫分析法检测甲型肝炎病毒（HAV）和乙型肝炎病毒（HBV）的血清学标志物，采用酶免疫分析法检测乙型肝炎核心抗原IgM抗体（IgM抗-HBc）。563例患者中，入院时503例（89.7%）乙型肝炎表面抗原（HBsAg）阳性，60例（10.7%）HBsAg阴性。与其他患者相比，可能通过异性途径感染的患者入院时HBsAg阴性的比例明显更高（23.3%对6.6%；P<0.001）。这一发现与性别无关。这些数据表明，HBV感染途径而非性别似乎在HBsAg的快速清除中起更重要的作用。