Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730, China.
Chin Med J (Engl). 2010 Sep;123(17):2310-4.
Multiple neonatal characteristics and adult cardiovascular risk factors are associated with the development of atherosclerosis, however little conclusive evidence exists characterizing the relative strength of these factors. In a large retrospective study, we investigated the association between both objective neonatal measurements and comprehensive adult cardiovascular risk factors with the development of atherosclerosis, quantified by carotid intima-media thickness (CIMT). Further, we assessed the impact of gender on the relative impact of these risk factors.
CIMT, a measure of atherosclerosis, was determined by carotid ultrasound on 1568 participants (age 50-85) whose birth records were obtained from Peking Union Medical College Hospital. In addition, each participant was given a physical examination, and completed a medical questionnaire to identify a panel of cardiovascular risk factors. Multiple regression analysis was performed on the population and on the male and female cohorts individually, to identify the relative contribution of these risk factors to increased CIMT.
For the total population the Framingham score, renal function, adult abdominal circumference and mother's gestational age were associated with CIMT, accounting for 14.7%, 1.4%, 0.9%, and 0.2% of total variance, respectively. In the male population the Framingham score, renal function, abdominal circumference and hemoglobin were the most significant risk factors for CIMT. Risk in the female population was associated with Framingham score, renal function, insulin resistance and gestational age. No relationship between birth weight or head circumference and CIMT were observed.
Adult cardiovascular risk factors were the most significantly associated with the development of atherosclerosis; however mother's age at birth was associated with CIMT, particularly in the female cohort. The relative contribution of the risk factors analyzed varied between the male and female populations.
多种新生儿特征和成年心血管危险因素与动脉粥样硬化的发展有关，但目前还没有确凿的证据表明这些因素的相对强度。在一项大型回顾性研究中，我们通过颈动脉内膜中层厚度（CIMT）来研究客观的新生儿测量值和综合的成年心血管危险因素与动脉粥样硬化发展之间的关系。此外，我们评估了性别对这些危险因素相对影响的影响。
1568 名年龄在 50-85 岁的参与者的颈动脉超声检查确定了动脉粥样硬化的指标 CIMT，他们的出生记录是从北京协和医学院医院获得的。此外，每位参与者都接受了体检，并填写了一份医学问卷，以确定一系列心血管危险因素。对人群以及男性和女性队列分别进行多元回归分析，以确定这些危险因素对增加 CIMT 的相对贡献。
对于总人群，弗雷明汉评分、肾功能、成年腹围和母亲的妊娠年龄与 CIMT 相关，分别占总方差的 14.7%、1.4%、0.9%和 0.2%。在男性人群中，弗雷明汉评分、肾功能、腹围和血红蛋白是与 CIMT 最相关的危险因素。女性人群的风险与弗雷明汉评分、肾功能、胰岛素抵抗和妊娠年龄相关。未观察到出生体重或头围与 CIMT 之间存在关系。
成年心血管危险因素与动脉粥样硬化的发展最密切相关；然而，母亲出生时的年龄与 CIMT 相关，尤其是在女性队列中。分析的危险因素的相对贡献在男性和女性人群之间有所不同。
