Timóteo Ana Teresa, Toste Alexandra, Araújo Alexandra, Ferreira Rui Cruz
Serviço Cardiologia e Serviço de Radiologia, Hospital de Santa Marta, Centro Hospitalar de Lisboa Central EPE, Lisboa, Portugal.
Rev Port Cardiol. 2010 Jul-Aug;29(7-8):1181-90.
Carotid intima-media thickness (cIMT) is considered an early marker for atherosclerosis, but there are few studies on the expression of this marker in younger populations.
To evaluate cIMT in younge patients (aged 30-50 years) and its expression according to cardiovascular risk factors.
We analyzed individuals admitted for an invasive cardiac procedure. Normal cIMT was defined as < 0.90 mm, thickened as 0.90-1.50 mm and atherosclerotic plaque as > 1.50 mm. Lipid profile, anthropometric parameters, fasting blood glucose and estimated GFR were also determined.
A total of 106 patients were included (59% male), with a mean age of 43 +/- 5 years, 36% with hypertension, 22% smokers, 32% with known hyperlipidemia, 16% with diabetes, 39% under statin therapy and 40% with metabolic syndrome (AHA/NHLBI definition). Mean cIMT was 0.69 +/- 0.26 mm, and was normal in 74% of the patients, thickened in 20% and with atherosclerotic plaques in 6%. cIMT correlated directly with age (r = 0.26, p = 0.007), log fasting glucose (r = 0.21, p = 0.04), and log triglycerides (r = 0.24, p = 0.017), and tended to correlate with the number of components of metabolic syndrome (r = 0.17, p = 0.08). However, on multivariate analysis, only age remained as an independent predictor (r = 0.29, p = 0.005). Diabetic patients had greater cIMT (0.81 +/- 0.22 vs. 0.67 +/- 0.26 mm, p = 0.039) and there was a trend for greater cIMT in those with metabolic syndrome (0.75 +/- 0.29 vs. 0.66 +/- 0.23 mm, p = 0.09). There were no differences for the other risk factors, A higher number of risk factors in a single patient showed a trend for increased cIMT (p = 0.083)
Age is the only independent determinant of cIMT in a young population. Diabetic patients have greater cIMT and a trend was seen in those with metabolic syndrome, possibly influenced by its relation with diabetes, one of the components of the metabolic syndrome.
颈动脉内膜中层厚度（cIMT）被认为是动脉粥样硬化的早期标志物，但关于该标志物在年轻人群中的表达情况研究较少。
评估年轻患者（30 - 50岁）的cIMT及其根据心血管危险因素的表达情况。
我们分析了因侵入性心脏手术入院的个体。正常cIMT定义为<0.90毫米，增厚为0.90 - 1.50毫米，动脉粥样硬化斑块为>1.50毫米。还测定了血脂谱、人体测量参数、空腹血糖和估算的肾小球滤过率。
共纳入106例患者（59%为男性），平均年龄43±5岁，36%患有高血压，22%为吸烟者，32%已知患有高脂血症，16%患有糖尿病，39%接受他汀类药物治疗，40%患有代谢综合征（美国心脏协会/美国国立心肺血液研究所定义）。平均cIMT为0.69±0.26毫米，74%的患者cIMT正常，20%增厚，6%有动脉粥样硬化斑块。cIMT与年龄直接相关（r = 0.26，p = 0.007）、与空腹血糖对数相关（r = 0.21，p = 0.04）以及与甘油三酯对数相关（r = 0.24，p = 0.017），并且倾向于与代谢综合征的组分数量相关（r = 0.17，p = 0.08）。然而，在多变量分析中，只有年龄仍然是独立预测因素（r = 0.29，p = 0.005）。糖尿病患者的cIMT更大（0.81±0.22对0.67±0.26毫米，p = 0.039），并且代谢综合征患者的cIMT有增大趋势（0.75±0.29对0.66±0.23毫米，p = 0.09）。其他危险因素无差异。单个患者中危险因素数量越多，cIMT有增大趋势（p = 0.083）
年龄是年轻人群中cIMT的唯一独立决定因素。糖尿病患者的cIMT更大，代谢综合征患者有此趋势，可能受其与糖尿病（代谢综合征的组分之一）的关系影响。
