Department of Pathology, First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Chin Med J (Engl). 2010 Oct;123(20):2832-5.
Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm, which shares some histologic features with thyroid papillary carcinoma (TPC). Clinically, it is frequently misdiagnosed as papillary carcinoma, even for some experienced pathologists. The aim of this study was to investigate whether HTT is variant of TPC or HTT is an independent entity of thyroid neoplasm.
The expression of CK19, galectin-3, HBME-1 and MIB-1 was detected by immunohistochemical staining in 12 cases of hyalinizing trabecular tumor and 20 cases of thyroid papillary carcinoma.
Two of the 12 HTT samples were positive or focally positive for CK19. Four of the 12 samples of HTT presented positive to galectin-3; 3 were stained strongly and the other one was focally positive. None of the 12 samples of HTT was positive for HBME-1. Five in 12 HTT samples were stained in nucleus for MIB-1. Almost all the 20 cases of thyroid papillary carcinoma were intensely stained for CK19, galectin-3 and HBME-1. Fifteen in 20 cases of thyroid papillary carcinoma showed nuclear staining for MIB-1.
HTT is an independent thyroid neoplasm, not a variant of TPC. This study could help in the differential diagnosis of HTT from TPC. CK19, galectin-3 and HBME-1 are adequate to identify HTT and TPC, but MIB-1 does not play an important role in discrimination between HTT and TPC.
玻璃样小梁状肿瘤（HTT）是一种罕见的甲状腺肿瘤，其具有与甲状腺乳头状癌（TPC）相似的组织学特征。临床上，它经常被误诊为乳头状癌，甚至对一些有经验的病理学家也是如此。本研究旨在探讨 HTT 是否是 TPC 的一种变体，还是甲状腺肿瘤的一个独立实体。
通过免疫组织化学染色检测 12 例 HTT 和 20 例甲状腺乳头状癌中 CK19、半乳糖凝集素-3、HBME-1 和 MIB-1 的表达。
12 例 HTT 中有 2 例 CK19 阳性或局灶阳性。12 例 HTT 中有 4 例半乳糖凝集素-3阳性；3 例强阳性，1 例局灶阳性。12 例 HTT 均无 HBME-1 阳性。12 例 HTT 中有 5 例 MIB-1 核染色阳性。20 例甲状腺乳头状癌中几乎所有病例均强烈表达 CK19、半乳糖凝集素-3 和 HBME-1。20 例甲状腺乳头状癌中有 15 例 MIB-1 核染色阳性。
HTT 是一种独立的甲状腺肿瘤，不是 TPC 的变体。本研究有助于 HTT 与 TPC 的鉴别诊断。CK19、半乳糖凝集素-3 和 HBME-1 足以识别 HTT 和 TPC，但 MIB-1 在区分 HTT 和 TPC 方面作用不大。
