Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Chin Med J (Engl). 2010 Oct;123(20):2948-54.
To review the role of epigenetic regulation in neonatal diseases and better understand Barker's "fetal origins of adult disease hypothesis".
The data cited in this review were mainly obtained from the articles published in Medline/PubMed between January 1953 and December 2009.
Articles associated with epigenetics and neonatal diseases were selected.
There is a wealth of epidemiological evidence that lower birth weight is strongly correlated with an increased risk of adult diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular disease. This phenomenon of fetal origins of adult disease is strongly associated with fetal insults to epigenetic modifications of genes. A potential role of epigenetic modifications in congenital disorders, transient neonatal diabetes mellitus (TNDM), intrauterine growth retardation (IUGR), and persistent pulmonary hypertension of the newborn (PPHN) have been studied.
Acknowledgment of the role of these epigenetic modifications in neonatal diseases would be conducive to better understanding the pathogenesis of these diseases, and provide new insight for improved treatment and prevention of later adult diseases.
探讨表观遗传调控在新生儿疾病中的作用，从而更好地理解 Barker 的“成人疾病的胎儿起源假说”。
本综述中引用的数据主要来源于 1953 年 1 月至 2009 年 12 月期间发表在 Medline/PubMed 上的文章。
选择与表观遗传学和新生儿疾病相关的文章。
大量的流行病学证据表明，低出生体重与成年疾病（如 2 型糖尿病、高血压和心血管疾病）的风险增加密切相关。这种成人疾病的胎儿起源现象与胎儿对基因表观遗传修饰的损伤密切相关。表观遗传修饰在先天性疾病、短暂性新生儿糖尿病（TNDM）、宫内发育迟缓（IUGR）和新生儿持续性肺动脉高压（PPHN）中的作用已被研究。
承认这些表观遗传修饰在新生儿疾病中的作用，有助于更好地理解这些疾病的发病机制，并为改善成年后疾病的治疗和预防提供新的思路。
