Mösges Ralph, El Hassan Eelaf, Passàli Desiderio
Institute of Medical Statistics, Informatics and Epidemiology, Cologne University Hospital, Cologne 50931, Germany.
Discov Med. 2010 Oct;10(53):348-54.
Sublingual application of allergen extracts in specific immunotherapy is a modern approach aimed at improving patient treatment acceptance through reduced serious side effects. This therapeutic approach has proven to be efficacious and safe for the treatment of allergies caused by airborne allergens: 1) studies have shown a rapid onset of action, as early as seven days after beginning treatment; 2) a strong effect during treatment, superior to most forms of symptomatic treatment; 3) a lasting effect after cessation; 4) a preventive effect against new sensitizations and new-onset asthma; and 5) an unprecedented safety profile compared to the subcutaneous route. SLIT is an established treatment option for moderate to severe allergic rhinoconjunctivitis with or without asthma, which can be given to adults as well as to children above five. The complexity of the treatment of this condition mandates expert care by an experienced allergologist.
在特异性免疫疗法中，舌下应用变应原提取物是一种现代治疗方法，旨在通过减少严重副作用来提高患者对治疗的接受度。这种治疗方法已被证明对治疗由空气传播变应原引起的过敏有效且安全：1）研究表明起效迅速，早在开始治疗后七天就可出现；2）治疗期间效果显著，优于大多数对症治疗形式；3）停止治疗后效果持久；4）对新的致敏和新发哮喘有预防作用；5）与皮下途径相比，具有前所未有的安全性。舌下特异性免疫疗法是治疗伴有或不伴有哮喘的中重度变应性鼻结膜炎的既定治疗选择，可用于成人以及五岁以上儿童。这种疾病治疗的复杂性要求由经验丰富的过敏症专科医生进行专业护理。
