纵向评估躁狂症状（LAMS）研究：背景、设计和初步筛选结果。
Longitudinal Assessment of Manic Symptoms (LAMS) study: background, design, and initial screening results.
机构信息
Department of Pediatrics and Stanford Health Policy, Stanford University School of Medicine, 117 Encina Commons, Stanford, CA 94305-6019, USA.
出版信息
J Clin Psychiatry. 2010 Nov;71(11):1511-7. doi: 10.4088/JCP.09m05835yel. Epub 2010 Oct 5.
OBJECTIVE
To describe the design of a longitudinal study of youth with elevated symptoms of mania (ESM), as well as the prevalence and correlates of manic symptoms. Bipolar disorder in youth is serious and is surrounded by controversy about its phenomenology, course, and treatment. Yet, there are no longitudinal studies of youth selected only for ESM, the phenomenological hallmark. The study's objective is to document the rate and sociodemographic correlates of ESM in children attending outpatient psychiatric clinics.
METHOD
Parents of 3,329 children aged 6-12 years visiting 10 outpatient clinics were asked to complete the Parent General Behavior Inventory 10-Item Mania Scale (PGBI-10M). Children with PGBI-10M scores ≥ 12 (ESM positive-screen [ESM+]) and a matched sample of ESM screen-negative (ESM-) children were invited to enroll in the longitudinal study. The sample was accrued from November 14, 2005, to November 28, 2008.
RESULTS
Most of the children whose parents filled out the PGBI-10M (N = 2,622, 78.8%) participated in the study. Nonparticipants were slightly younger (mean age = 9.1 years [SD = 2.0 years] versus 9.4 years [SD = 2.0 years] for participants; t3327 = 4.42, P < .001). Nearly half of the participants (43%) were ESM+; these were more likely to be Latino (4.2% versus 2.5% for ESM-; χ(2)1 = 5.45, P = .02), younger (mean age = 9.3 years [SD = 2.0 years] versus 9.6 years [SD = 1.9 years] for ESM-; t2620 = 3.8, P < .001), and insured by Medicaid (48.4% versus 35.4% for ESM-; χ(2)1 = 45.00, P < .001). There were no sociodemographic differences between those who did versus did not agree to enroll in the longitudinal portion (yes to enrollment: n = 621, 55.2%; no to enrollment: n = 503, 44.8%). Four items best discriminated ESM+ children from ESM- children. Three of the 4 items were not the most commonly endorsed items, but all were indicative of behavioral extremes.
CONCLUSIONS
Data suggest that ESM+ is not rare in 6- to 12-year-olds. Children who are ESM+ show behavioral extremes, including rapid mood shifts, compared to ESM- children.
目的
描述一项针对有明显躁狂症状的青年（ESM）的纵向研究的设计，以及躁狂症状的流行率和相关因素。青年双相情感障碍是严重的，并且围绕着其表现、病程和治疗存在争议。然而，目前尚无仅针对 ESM（表现标志）的青年纵向研究。该研究的目的是记录在 10 家门诊精神病诊所就诊的儿童中 ESM 的发生率和社会人口统计学相关因素。
方法
对 10 家门诊诊所的 3329 名 6-12 岁儿童的父母进行问卷调查，要求他们填写《父母一般行为清单 10 项躁狂量表》（PGBI-10M）。PGBI-10M 得分≥12（ESM 阳性筛查[ESM+]）的儿童和匹配的 ESM 阴性筛查（ESM-）儿童受邀参加纵向研究。样本采集于 2005 年 11 月 14 日至 2008 年 11 月 28 日。
结果
大多数填写了 PGBI-10M 的儿童父母（N=2622，78.8%）参加了该研究。未参与者略年轻（平均年龄=9.1 岁[SD=2.0 岁]与参与者的 9.4 岁[SD=2.0 岁]；t3327=4.42，P<.001）。近一半的参与者（43%）为 ESM+；这些儿童更有可能是拉丁裔（4.2%比 ESM-的 2.5%；χ(2)1=5.45，P=.02），年龄更小（平均年龄=9.3 岁[SD=2.0 岁]与 ESM-的 9.6 岁[SD=1.9 岁]；t2620=3.8，P<.001），并且由医疗补助计划（Medicaid）承保（48.4%比 ESM-的 35.4%；χ(2)1=45.00，P<.001）。那些同意与不同意参加纵向部分的人之间没有社会人口统计学差异（同意参加：n=621，55.2%；不同意参加：n=503，44.8%）。有四个项目可以最好地区分 ESM+儿童和 ESM-儿童。这四个项目中的三个不是最常被认可的项目，但都表明存在行为极端。
结论
数据表明，6 至 12 岁儿童中 ESM+并不罕见。与 ESM-儿童相比，ESM+的儿童表现出行为极端，包括情绪快速变化。
Zotero 插件