Department of Molecular Biology and Functional Genomics, Stockholm University, SE-10691 Stockholm, Sweden.
Res Microbiol. 2011 Jan;162(1):71-6. doi: 10.1016/j.resmic.2010.10.002. Epub 2010 Oct 27.
An archaeal origin of eukaryotes is often equated with the engulfment of the bacterial ancestor of mitochondria by an archaeon. Such an event is problematic in that it is not supported by archaeal cell biology. We show that placing phylogenetic results within a stem-and-crown framework eliminates such incompatibilities, and that an archaeal origin for eukaryotes (as suggested from recent phylogenies) can be uncontroversially reconciled with phagocytosis as the mechanism for engulfment of the mitochondrial ancestor. This is significant because it eliminates a perceived problem with eukaryote origins: that an archaeal origin of eukaryotes (as under the Eocyte hypothesis) cannot be reconciled with existing cell biological mechanisms through which bacteria may take up residence inside eukaryote cells.
真核生物的古菌起源通常等同于被古菌吞噬的细菌祖先的线粒体。这样的事件是有问题的，因为它没有得到古菌细胞生物学的支持。我们表明，将系统发育结果置于茎-冠框架内可以消除这种不兼容性，并且真核生物（如最近的系统发育所表明的那样）的起源可以与吞噬作用作为吞噬线粒体祖先的机制毫无争议地协调一致。这是重要的，因为它消除了一个与真核生物起源有关的问题：即真核生物的古菌起源（如在 Eocyte 假说下）不能与细菌可能在真核细胞内定居的现有细胞生物学机制相协调。
