人体布鲁氏菌病的细胞介导免疫。
Cell-mediated immunity in human brucellosis.
机构信息
First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
出版信息
Microbes Infect. 2011 Feb;13(2):134-42. doi: 10.1016/j.micinf.2010.10.015. Epub 2010 Oct 27.
Brucella can parasitize within human antigen-presenting cells modifying phagocytosis, phagolysosome fusion, antigen presentation, cytokine secretion, and apoptosis. Subversion of innate immune mechanisms by Brucella leads to defective Th1 immune responses and T-cell anergy in chronic brucellosis patients. This review summarizes the cellular immune responses in brucellosis, based on data derived exclusively from human cells or cell lines.
布鲁氏菌可以寄生于人体抗原呈递细胞内，从而改变吞噬作用、吞噬溶酶体融合、抗原呈递、细胞因子分泌和细胞凋亡。布鲁氏菌对内源性免疫机制的颠覆导致慢性布鲁氏菌病患者中 Th1 免疫应答缺陷和 T 细胞无能。本综述根据仅源自人类细胞或细胞系的数据，总结了布鲁氏菌病中的细胞免疫应答。
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