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感染和 Toll 样受体。

infection and Toll-like receptors.

机构信息

Inner Mongolia Key Laboratory of Disease-Related Biomarkers, The Second Affiliated Hospital, Baotou Medical College, Baotou, China.

School of Basic Medicine, Baotou Medical College, Baotou, China.

出版信息

Front Cell Infect Microbiol. 2024 Mar 12;14:1342684. doi: 10.3389/fcimb.2024.1342684. eCollection 2024.

DOI:10.3389/fcimb.2024.1342684
PMID:38533384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10963510/
Abstract

consists of gram-negative bacteria that have the ability to invade and replicate in professional and non-professional phagocytes, and its prolonged persistence in the host leads to brucellosis, a serious zoonosis. Toll-like receptors (TLRs) are the best-known sensors of microorganisms implicated in the regulation of innate and adaptive immunity. In particular, TLRs are transmembrane proteins with a typical structure of an extracellular leucine-rich repeat (LRR) region and an intracellular Toll/interleukin-1 receptor (TIR) domain. In this review, we discuss infection and the aspects of host immune responses induced by pathogens. Furthermore, we summarize the roles of TLRs in infection, with substantial emphasis on the molecular insights into its mechanisms of action.

摘要

布鲁氏菌病是一种由革兰氏阴性细菌引起的疾病，这些细菌能够侵入并在专业和非专业吞噬细胞中复制，如果这些细菌在宿主体内持续存在，就会导致布鲁氏菌病，这是一种严重的人畜共患病。Toll 样受体 (TLR) 是已知的微生物传感器，与先天免疫和适应性免疫的调节有关。特别是，TLR 是具有典型结构的跨膜蛋白，其胞外区富含亮氨酸重复序列 (LRR)，胞内区为 Toll/白细胞介素-1 受体 (TIR) 结构域。在本综述中，我们讨论了 感染以及病原体引起的宿主免疫反应的各个方面。此外，我们总结了 TLR 在 感染中的作用，重点介绍了其作用机制的分子见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/951e/10963510/da8ca0c26ec6/fcimb-14-1342684-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/951e/10963510/5313959549bd/fcimb-14-1342684-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/951e/10963510/da8ca0c26ec6/fcimb-14-1342684-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/951e/10963510/5313959549bd/fcimb-14-1342684-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/951e/10963510/da8ca0c26ec6/fcimb-14-1342684-g002.jpg

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Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo.源自 SLAMF1 的肽可预防 TLR4 介导的体内外炎症。
Life Sci Alliance. 2023 Oct 3;6(12). doi: 10.26508/lsa.202302164. Print 2023 Dec.
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Outer membrane protein 25 of Brucella suppresses TLR-mediated expression of proinflammatory cytokines through degradation of TLRs and adaptor proteins.
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