Colmenares C, Stavnezer E
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center, OH 45267-0524.
Semin Cancer Biol. 1990 Dec;1(6):383-7.
The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses. V-ski transformation causes increased proliferation of embryo fibroblasts and also induces a number of genes characteristic of the muscle lineage. In natural SKV isolates the 49 kDa v-ski polypeptide is expressed as a fusion protein with N-terminal gag and other viral sequences. The cellular homologue of v-ski, c-ski, is a large gene comprising at least 70 kb and containing at least seven coding exons. V-ski consists of most of the first five coding exons of c-ski. The proteins encoded by both genes are nuclear proteins that bind DNA and contain recognised motifs common to known nuclear regulatory proteins. A c-ski-related gene called sno has also been recently identified and, like c-ski, it is expressed in several human tumour cell lines.
ski癌基因是缺陷型SKV禽癌病毒的转化基因v-ski。v-ski转化导致胚胎成纤维细胞增殖增加，并诱导一些肌肉谱系特有的基因。在天然SKV分离株中，49 kDa的v-ski多肽作为与N端gag和其他病毒序列的融合蛋白表达。v-ski的细胞同源物c-ski是一个大基因，至少包含70 kb，含有至少七个编码外显子。v-ski由c-ski的前五个编码外显子中的大部分组成。这两个基因编码的蛋白质都是结合DNA的核蛋白，并含有已知核调节蛋白共有的公认基序。最近还鉴定出一个与c-ski相关的基因sno，与c-ski一样，它在几种人类肿瘤细胞系中表达。
