Department of Biochemistry and Molecular Biology, Southern Alberta Cancer Research Institute, University of Calgary, Alberta, T2N 4N1 Canada.
Curr Mol Med. 2010 Oct;10(7):667-73. doi: 10.2174/156652410792630616.
The transcriptional regulator SnoN has been the subject of growing interest due to its diverse functions in normal and pathological settings. A large body of evidence has established a fundamental role for SnoN as a modulator of signaling and responses by the transforming growth beta (TGFbeta) family of cytokines, though how SnoN regulates TGFbeta responses remains incompletely understood. In accordance with the critical and complex roles of TGFbeta in tumorigenesis and metastasis, SnoN may act as a tumor promoter or suppressor depending on the stage and type of cancer. Beyond its role in cancer, SnoN has also been implicated in the control of axon morphogenesis in postmitotic neurons in the mammalian brain. Remarkably, signaling pathways that control SnoN functions in the divergent cycling cells and postmitotic neurons appear to be conserved. Identification of novel SnoN regulatory and effector mechanisms holds the promise of advances at the interface of cancer biology and neurobiology.
转录调节因子 SnoN 因其在正常和病理环境中的多种功能而受到越来越多的关注。大量证据表明，SnoN 作为转化生长β（TGFβ）细胞因子家族信号转导和反应的调节剂具有重要作用，尽管 SnoN 如何调节 TGFβ 反应仍不完全清楚。根据 TGFβ 在肿瘤发生和转移中的关键和复杂作用，SnoN 可能根据癌症的阶段和类型发挥肿瘤促进或抑制作用。除了在癌症中的作用外，SnoN 还被牵连到哺乳动物大脑中已分化神经元的轴突形态发生的控制中。值得注意的是，控制 SnoN 在不同周期细胞和已分化神经元中的功能的信号通路似乎是保守的。鉴定新的 SnoN 调节和效应机制有望在癌症生物学和神经生物学的界面取得进展。
