Yasumatsu Ryuji, Nakashima Torahiko, Yamauchi Moriyasu, Wakasaki Takahiro, Masuda Muneyuki, Komune Shizuo
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, Japan.
Auris Nasus Larynx. 2011 Jun;38(3):387-91. doi: 10.1016/j.anl.2010.07.011. Epub 2010 Oct 28.
The aim of this study was to evaluate the immunohistochemical TS expression in patients with maxillary sinus SCC.
The value of immunohistochemical TS expression as a predictive indicator for 5-FU efficacy was retrospectively examined in 47 patients with maxillary sinus SCC.
Of the 47 patients, 29 (62%) showed complete response for 5-FU based chemoradiotherapy. Seventeen of 19 (89%) TS low cases showed a complete response, whereas 12 of 28 (43%) TS high cases showed complete response for 5-FU based chemoradiotherapy. Low TS patients had significantly better response rates compared with high TS patients.
These findings suggest that TS expression affects the chemotherapeutic effect of 5-FU in patients with maxillary sinus SCC and the assessment of TS expression level might be useful both in the management and in the treatment of maxillary sinus SCC.
本研究旨在评估上颌窦鳞状细胞癌（SCC）患者中胸苷酸合成酶（TS）的免疫组化表达情况。
对47例上颌窦SCC患者进行回顾性研究，检测免疫组化TS表达作为5-氟尿嘧啶（5-FU）疗效预测指标的价值。
47例患者中，29例（62%）对基于5-FU的放化疗表现出完全缓解。19例TS低表达患者中有17例（89%）表现出完全缓解，而28例TS高表达患者中有12例（43%）对基于5-FU的放化疗表现出完全缓解。与TS高表达患者相比，TS低表达患者的缓解率显著更高。
这些发现表明，TS表达影响上颌窦SCC患者对5-FU的化疗效果，TS表达水平的评估在上颌窦SCC的管理和治疗中可能都有用。
