Dipartimento di Scienze Cliniche 'Luigi Sacco', Università degli Studi di Milano, Italy.
Bioorg Med Chem. 2010 Dec 1;18(23):8396-402. doi: 10.1016/j.bmc.2010.09.030. Epub 2010 Sep 18.
A series of adenosine analogues differently substituted in N⁶-position were synthesized to continue our studies on the relationships between structure and biological activity of iPA. The structures of the compounds were confirmed by standard studies of ¹H NMR, MS and elemental analysis. These molecules were then evaluated for their anti-proliferative activity on bladder cancer cells. We found that some of these compounds possess anti-proliferative activity but have no effect on cell invasion and metalloprotease activity.
我们合成了一系列在 N⁶ 位不同取代的腺嘌呤类似物，以继续研究 iPA 的结构与生物活性之间的关系。通过对¹H NMR、MS 和元素分析的标准研究证实了这些化合物的结构。然后，我们评估了这些分子对膀胱癌细胞的抗增殖活性。我们发现，其中一些化合物具有抗增殖活性，但对细胞侵袭和金属蛋白酶活性没有影响。
