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新型吡唑并[1,5-a]嘧啶的合成及其抗肿瘤活性

Synthesis and anti-tumor activities of novel pyrazolo[1,5-a]pyrimidines.

作者信息

Li Juan, Zhao Yan Fang, Zhao Xiang Lin, Yuan Xiao Ye, Gong Ping

机构信息

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, P. R. China.

出版信息

Arch Pharm (Weinheim). 2006 Nov;339(11):593-7. doi: 10.1002/ardp.200600098.

DOI:10.1002/ardp.200600098
PMID:17036367
Abstract

A series of novel pyrazolo[1,5-a]pyrimidines were designed and synthesized in order to find novel potent anti-tumor compounds. The structures of all the compounds were confirmed by IR, (1)H-NMR, elemental analysis, and MS. Their anti-tumor activities against cancer cell lines were tested by the MTT method in vitro. Compound 19 displayed potent anti-tumor activity.

摘要

为了寻找新型高效的抗肿瘤化合物，设计并合成了一系列新型吡唑并[1,5 - a]嘧啶。所有化合物的结构均通过红外光谱（IR）、氢核磁共振谱（¹H - NMR）、元素分析和质谱（MS）得以确证。采用MTT法在体外测试了它们对癌细胞系的抗肿瘤活性。化合物19表现出较强的抗肿瘤活性。

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