呼吸道合胞病毒感染中的宿主和病毒因素
Host and Viral Factors in Respiratory Syncytial Virus Infection.
作者信息
Mastrangelo Peter, Hegele Richard G
机构信息
1Department of Laboratory Medicine and Pathobiology, University of Toronto, 6231-1 King's College Circle, Toronto, ON M5S 1A8 Canada.
2Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON Canada.
出版信息
Curr Pediatr Rep. 2013;1(3):149-157. doi: 10.1007/s40124-013-0019-3. Epub 2013 May 15.
Respiratory syncytial virus (RSV) is a major worldwide pathogen for which there is still no effective vaccine or antiviral treatment available, and immunoprophylaxis with RSV-specific antibodies (e.g., palivizumab) is used in limited clinical settings. In this review, we discuss virus-host interactions relevant to RSV pathobiology and how advances in cell and systems biology have accelerated knowledge in this area. We also highlight recent advances in understanding the relationship between RSV bronchiolitis and sequelae of recurrent wheezing and asthma, new findings into an intriguing interaction between RSV and air pollution, and exciting developments toward the goal of realizing a safe and effective RSV vaccine.
呼吸道合胞病毒（RSV）是一种全球范围内的主要病原体，目前仍没有有效的疫苗或抗病毒治疗方法，并且仅在有限的临床环境中使用针对RSV的特异性抗体进行免疫预防（例如帕利珠单抗）。在这篇综述中，我们讨论了与RSV发病机制相关的病毒-宿主相互作用，以及细胞生物学和系统生物学的进展如何加速了该领域的知识积累。我们还重点介绍了在理解RSV细支气管炎与复发性喘息和哮喘后遗症之间关系方面的最新进展、关于RSV与空气污染之间有趣相互作用的新发现，以及在实现安全有效的RSV疫苗目标方面令人振奋的进展。
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