Centre National de Référence des Entérovirus, Laboratoire de Virologie Est des Hospices Civils de Lyon, Groupement Hospitalier Est, 59 boulevard Pinel, F-69677 Bron Cedex, France.
J Clin Virol. 2011 Jan;50(1):50-6. doi: 10.1016/j.jcv.2010.09.019. Epub 2010 Oct 28.
Human enterovirus 71 (EV-71) emerged as a significant pathogen able to cause large outbreaks involving severe neurological cases and children fatalities in Asia.
To describe epidemiology of EV-71 infections in France.
Fifty-nine patients admitted in 12 different hospitals from 1994 to 2009 were included. The entire VP1 coding gene of 58 EV-71 strains was sequenced and phylogenetic analyses were performed to assign strains to genogroups/subgenogroups and to compare French isolates to European and worldwide isolates.
The median age of the patients was 1.04 years (9 days to 7 years). Among 46 documented EV-71 infections, 39 were self-limited. Seven children developed severe sepsis-like, respiratory or neurological complications. Among them, 2 children died from acute respiratory distress syndrome. All the EV-71 strains belonged to genogroup C: 31 isolates belonged to subgenogroup C1, 26 to subgenogroup C2 and 1 to subgenogroup C4. All the strains were genetically related to other European strains isolated at the same period of time. Although C1 isolates were predominant between 1994 and 2005, C2 strains have been predominant since 2007. No association was found between any genotype and the age or the clinical symptoms.
The C4 subgenogroup, which was associated with large outbreaks in China, did not spread in France. It is important to monitor more carefully the EV-71 strains circulating in France to detect the introduction of new genetic variants that could be associated with major outbreaks.
肠道病毒 71 型（EV-71）已成为亚洲地区引发大规模暴发、导致严重神经系统疾病和儿童死亡的重要病原体。
描述法国 EV-71 感染的流行病学情况。
纳入了 1994 年至 2009 年期间 12 家不同医院收治的 59 例患者。对 58 株 EV-71 病毒的 VP1 编码基因全长进行了测序，并进行了系统进化分析，以确定病毒株的基因亚型/亚属，并将法国分离株与欧洲和全球分离株进行比较。
患者的中位年龄为 1.04 岁（9 天至 7 岁）。在 46 例有记录的 EV-71 感染中，39 例为自限性。7 例患儿出现严重脓毒症样、呼吸或神经系统并发症。其中 2 例患儿死于急性呼吸窘迫综合征。所有 EV-71 株均属于基因 C 组：31 株属于 C1 亚组，26 株属于 C2 亚组，1 株属于 C4 亚组。所有分离株与同期欧洲分离株在基因上具有亲缘关系。尽管 C1 亚组在 1994 年至 2005 年期间占主导地位，但自 2007 年以来，C2 株已占主导地位。任何基因型与年龄或临床症状之间均无相关性。
与中国大规模暴发相关的 C4 亚组并未在法国传播。密切监测法国流行的 EV-71 株，以发现可能与大规模暴发相关的新型基因变异株非常重要。
