Diedrich Sabine, Weinbrecht Anna, Schreier Eckart
Robert Koch Institute, Berlin, Germany.
Arch Virol. 2009;154(7):1139-42. doi: 10.1007/s00705-009-0413-x. Epub 2009 Jun 9.
Enterovirus 71 (EV71) has emerged as a significant pathogen with potential to cause large outbreaks. Because little is known about its seroprevalence and molecular epidemiology in Germany, data for 1997-2007 are presented. Four hundred thirty-six sera from persons aging 10 months to 75 years were tested in a neutralisation test; 63.4% of pre-school children were seronegative, whereas about 75% of adults had antibodies to EV71. Phylogenetic analysis of 28 isolates associated with neurological or cutaneous manifestations showed that isolates belonging to genogroup C1 predominated in 2000-2005, followed by a change to genogroup C2 in 2006 and 2007. This shows the importance of monitoring the diversity of one of the most relevant neurotropic enteroviruses.
肠道病毒71型（EV71）已成为一种有可能引发大规模疫情的重要病原体。由于德国对其血清流行率和分子流行病学了解甚少，现提供1997 - 2007年的数据。对436份年龄在10个月至75岁人群的血清进行了中和试验检测；63.4%的学龄前儿童血清学呈阴性，而约75%的成年人具有EV71抗体。对28株与神经或皮肤表现相关的分离株进行系统发育分析表明，C1基因群的分离株在2000 - 2005年占主导地位，随后在2006年和2007年转变为C2基因群。这表明监测最相关的嗜神经性肠道病毒之一的多样性具有重要意义。
