Université H. Poincaré, B.P.70239, 54506 Vandœuvre-les-Nancy, France.
Physiol Behav. 2011 Feb 1;102(2):175-80. doi: 10.1016/j.physbeh.2010.10.018. Epub 2010 Oct 28.
Nasal obstruction is a risk factor in sleep-disordered breathing with a negative impact on the quality of life in humans. We investigated hydration changes produced by short term reversible, bilateral, nasal obstruction in young developing rat pups. Physiological parameters of growth (weight gain and gastric content weight) and dehydration were analyzed during two periods; during nasal obstruction at post-natal day 8 (days 9, 11 and 13), plus 7 and 90 days after recovery of nasal breathing (day 15 and adulthood). Body weight gain in oral breathing rat pups was slower compared to controls. Gastric weight was decreased significantly only in oral breathing rat pups on days 9 and 11 while plasma osmolality and vasopressin levels increased (indicators of dehydration). There were no differences between controls and treated rat pups by day 15, or at adulthood. Short term nasal obstruction-induced forced oral breathing, decreased gastric content which had a negative impact on growth and blood glucose concentration in the short term for female rat pups. Plasma corticosterone levels increased during the dehydration but were normal in males by 90 days. This could be a model for blocked nose syndrome in the newborn. Possible long term consequences on development are discussed.
鼻腔阻塞是睡眠呼吸障碍的一个危险因素，会对人类的生活质量产生负面影响。我们研究了短期可逆性双侧鼻腔阻塞对幼鼠生长发育的影响。在两个时期分析了生长生理参数（体重增加和胃内容物重量）和脱水情况：在出生后第 8 天（第 9、11 和 13 天）进行鼻腔阻塞，以及恢复鼻腔呼吸后 7 天和 90 天（第 15 天和成年期）。与对照组相比，口腔呼吸的幼鼠体重增加较慢。仅在第 9 和 11 天口腔呼吸的幼鼠胃重量显著减少，而血浆渗透压和血管加压素水平升高（脱水的指标）。到第 15 天或成年期，对照组和处理组之间没有差异。短期鼻腔阻塞导致的强制口腔呼吸、胃内容物减少，对雌性幼鼠的生长和短期血糖浓度产生负面影响。在脱水期间，血浆皮质酮水平升高，但 90 天后雄性正常。这可能是新生儿鼻塞综合征的一个模型。还讨论了可能对发育产生的长期影响。
