Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
J Ethnopharmacol. 2011 Jan 27;133(2):621-8. doi: 10.1016/j.jep.2010.10.043. Epub 2010 Oct 28.
Cinnamomum cassia (C. cassia) has been traditionally used to treat allergic disease as well as dyspepsia, gastritis, and blood circulation disturbances. However, the antiallergic properties of C. cassia have not been fully verified using scientific tools. This study investigated the effectiveness of C. cassia extract (CCE) as an antiallergic agent in atopic dermatitis model and underlying mechanism.
The effect of CCE on mite antigen-treated NC/Nga mice was evaluated by examining skin symptom severity, levels of serum IgE, tumor necrosis factor-α (TNF-α), and histamine, skin histology, and mRNA expression of cytokines in the skin lesions. Moreover, the effect of CCE on TNF-α-and interferon-γ (IFN-γ)-induced chemokine production in human keratinocytes was investigated using ELISA.
CCE treatment of NC/Nga mice reduced the dermatitis score and the levels of serum IgE, histamine, and TNF-α. Histological examination showed inhibition of the thickening of the epidermis/dermis and reduced dermal infiltration of inflammatory cells. In skin lesions, mRNA expression of IL-4, TNF-α, and thymus and activation-regulated chemokine (TARC) was inhibited by CCE treatment. The production of TARC, macrophage-derived chemokine, and RANTES from IFN-γ-and TNF-α-stimulated human keratinocytes was suppressed by CCE treatment in a dose-dependent manner.
CCE inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice by suppressing the T-helper 2 cell response.
肉桂（C. cassia）传统上用于治疗过敏疾病以及消化不良、胃炎和血液循环紊乱。然而，肉桂的抗过敏特性尚未通过科学工具得到充分验证。本研究旨在探讨肉桂提取物（CCE）作为变应性皮肤病模型和潜在机制的抗过敏药物的有效性。
通过观察皮肤症状严重程度、血清 IgE、肿瘤坏死因子-α（TNF-α）和组胺水平、皮肤组织学以及皮肤病变中细胞因子的 mRNA 表达，评估 CCE 对螨抗原处理的 NC/Nga 小鼠的作用。此外，通过 ELISA 研究 CCE 对 TNF-α 和干扰素-γ（IFN-γ）诱导的人角质形成细胞趋化因子产生的影响。
CCE 治疗 NC/Nga 小鼠可降低皮炎评分以及血清 IgE、组胺和 TNF-α水平。组织学检查显示表皮/真皮增厚和真皮炎症细胞浸润减少。在皮肤病变中，CCE 治疗可抑制 IL-4、TNF-α 和胸腺激活调节趋化因子（TARC）的 mRNA 表达。CCE 以剂量依赖的方式抑制 IFN-γ 和 TNF-α 刺激的人角质形成细胞中 TARC、巨噬细胞衍生趋化因子和 RANTES 的产生。
CCE 通过抑制辅助性 T 细胞反应抑制 NC/Nga 小鼠类似特应性皮炎的皮肤病变的发展。
