University Hospital Basel, Switzerland.
Cell Metab. 2010 Nov 3;12(5):427-8. doi: 10.1016/j.cmet.2010.10.002.
IL-1β is a major regulator of islet inflammation in type 2 diabetes. Several factors contribute to the induction of islet-derived IL-1β, including glucose, free fatty acids, and leptin. A recent report in Nature Immunology (Masters et al., 2010) identifies amyloid polypeptide as an additional enhancer of IL-1β production.
IL-1β 是 2 型糖尿病胰岛炎症的主要调节因子。几种因素导致胰岛产生的 IL-1β 增加，包括葡萄糖、游离脂肪酸和瘦素。《自然免疫学》（Nature Immunology）上的一篇最新报告（Masters 等人，2010 年）指出，淀粉样多肽是 IL-1β 产生的另一个增强因子。
