慢性肺部疾病患儿听觉功能的研究。
Study of auditory function in children with chronic lung diseases.
作者信息
Ibrahim Hanan M, Kamel Terez B, Abdel-Salam Nithreen M S, Abu-Ata S R
机构信息
Pediatrics Department, Ain Shams University, Cairo, Egypt.
出版信息
Int J Pediatr Otorhinolaryngol. 2011 Jan;75(1):39-42. doi: 10.1016/j.ijporl.2010.10.002. Epub 2010 Oct 29.
OBJECTIVE
Chronic hypoxia has an evident effect on cochlear function and hearing sensitivity. Otoacoustic emissions' testing is efficient in detecting subtle cochlear dysfunction. This cross sectional study was designed to assess the cochlear function in children with chronic lung diseases who were exposed to prolonged hypoxia and prolonged use of ototoxic drugs (as aminoglycosides) using basic audiological evaluation and transient evoked otoacoustic emissions testing.
METHODS
The study was carried out on 30 Egyptian children with chronic lung disease recruited from the Pediatric Chest Clinic, Children's hospital, Ain Shams University. Twenty normal children were included as control.
RESULTS
Six patients (20%) showed abnormal otoacoustic emissions. A significant effect of hypoxia on otoacoustic emissions findings was found (P<0.05). However, there was no significant effect of inhaled aminoglycosides on auditory functions whether pure tone audiometry, speech audiometry and transient evoked otoacoustic emissions testing.
CONCLUSIONS
Children with chronic lung diseases are liable to cochlear dysfunction due to prolonged hypoxia. Inhaled aminoglycosides in chronic lung diseases is relatively safe on auditory functions.
目的
慢性缺氧对耳蜗功能和听力敏感度有明显影响。耳声发射测试在检测细微的耳蜗功能障碍方面很有效。本横断面研究旨在通过基本听力学评估和瞬态诱发耳声发射测试，评估长期处于缺氧状态且长期使用耳毒性药物（如氨基糖苷类）的慢性肺部疾病患儿的耳蜗功能。
方法
该研究对从艾因夏姆斯大学儿童医院儿科胸科诊所招募的30名埃及慢性肺部疾病患儿进行。纳入20名正常儿童作为对照。
结果
6名患者（20%）耳声发射异常。发现缺氧对耳声发射结果有显著影响（P<0.05）。然而，无论是纯音听力测定、言语听力测定还是瞬态诱发耳声发射测试，吸入氨基糖苷类药物对听觉功能均无显著影响。
结论
慢性肺部疾病患儿由于长期缺氧易发生耳蜗功能障碍。慢性肺部疾病中吸入氨基糖苷类药物对听觉功能相对安全。
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