Kamel Terez Boshra, Abd Elmonaem Mahmoud Tarek, Khalil Lobna Hamed, Goda Mona Hamdy, Sanyelbhaa Hossam, Ramzy Mourad Alfy
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Audiology Unit, Department of Otolaryngology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Eur Arch Otorhinolaryngol. 2016 Oct;273(10):3413-20. doi: 10.1007/s00405-016-4044-z. Epub 2016 Apr 13.
Chronic lung disease (CLD) in children represents a heterogeneous group of many clinico-pathological entities with risk of adverse impact of chronic or intermittent hypoxia. So far, few researchers have investigated the cognitive function in these children, and the role of auditory P300 in the assessment of their cognitive function has not been investigated yet. This study was designed to assess the cognitive functions among schoolchildren with different chronic pulmonary diseases using both auditory P300 and Stanford-Binet test. This cross-sectional study included 40 school-aged children who were suffering from chronic chest troubles other than asthma and 30 healthy children of similar age, gender and socioeconomic state as a control group. All subjects were evaluated through clinical examination, radiological evaluation and spirometry. Audiological evaluation included (basic otological examination, pure-tone, speech audiometry and immittancemetry). Cognitive function was assessed by auditory P300 and psychological evaluation using Stanford-Binet test (4th edition). Children with chronic lung diseases had significantly lower anthropometric measures compared to healthy controls. They had statistically significant lower IQ scores and delayed P300 latencies denoting lower cognitive abilities. Cognitive dysfunction correlated to severity of disease. P300 latencies were prolonged among hypoxic patients. Cognitive deficits in children with different chronic lung diseases were best detected using both Stanford-Binet test and auditory P300. P300 is an easy objective tool. P300 is affected early with hypoxia and could alarm subtle cognitive dysfunction.
儿童慢性肺病（CLD）是一组由多种临床病理实体组成的异质性疾病，存在慢性或间歇性缺氧产生不良影响的风险。到目前为止，很少有研究人员对这些儿童的认知功能进行调查，而且听觉P300在评估他们认知功能中的作用尚未得到研究。本研究旨在使用听觉P300和斯坦福-比奈测试评估患有不同慢性肺病的学龄儿童的认知功能。这项横断面研究纳入了40名患有除哮喘外慢性胸部疾病的学龄儿童以及30名年龄、性别和社会经济状况相似的健康儿童作为对照组。所有受试者均通过临床检查、影像学评估和肺活量测定进行评估。听力评估包括（基本耳科检查、纯音、言语测听和声导抗测试）。认知功能通过听觉P300评估以及使用斯坦福-比奈测试（第4版）进行心理评估。与健康对照组相比，患有慢性肺病的儿童人体测量指标明显更低。他们的智商得分在统计学上显著更低，且P300潜伏期延迟，表明认知能力较低。认知功能障碍与疾病严重程度相关。缺氧患者的P300潜伏期延长。使用斯坦福-比奈测试和听觉P300能最好地检测出患有不同慢性肺病儿童的认知缺陷。P300是一种简便的客观工具。P300早期受缺氧影响，并可警示细微的认知功能障碍。
