University Montpellier 1, Laboratory Epsylon, EA-4206 Addictive, Performance and Health Behaviors, 4 Boulevard Henri IV, Montpellier F-34000, France.
Respir Med. 2011 Mar;105(3):377-85. doi: 10.1016/j.rmed.2010.10.002. Epub 2010 Oct 29.
Although the benefits of comprehensive pulmonary rehabilitation have been demonstrated in patients with COPD, the effects of exercise sessions within self-management programs remain unclear. We hypothesized that 8 supervised exercise sessions incorporated in a 1-month self-management education program in COPD patients would be effective to improve health outcomes and to reduce direct medical costs after one year, compared to usual care.
In this randomized controlled trial, 38 moderate-to-severe COPD patients were assigned either to an intervention group or to a usual care group. The hospital-based intervention program provided a combination of 8 sessions of supervised exercise with 8 self-management education sessions over a 1-month period. The primary end-point was the 6-min walking distance (6MWD), with secondary outcomes being health-related quality of life (HRQoL)--using the St. George's Respiratory Questionnaire (SGRQ) and Nottingham Health Profile (NHP), maximal exercise capacity and healthcare utilization. Data were collected before and one year after the program.
After 12 months, we found statistically significant between-group differences in favor of the intervention group in 6MWD (+50.5 m (95%CI, 2 to 99), in two domains of NHP (energy, -19.8 (-38 to -1); emotional reaction, -10.4 (-20 to 0)); in SGRQ-symptoms (-14.0 (-23 to -5)), and in cost of COPD medication (-480.7 € (CI, -891 to -70) per patient per year).
The present hospital-based intervention combining supervised exercise with self-management education provides significant improvements in patient's exercise tolerance and HRQoL, and significant decrease of COPD medication costs, compared to usual care.
虽然综合肺康复对 COPD 患者的益处已得到证实,但自我管理计划中运动课程的效果仍不清楚。我们假设,与常规护理相比,在 COPD 患者的 1 个月自我管理教育计划中纳入 8 次监督运动,将有效改善健康结局并降低一年后的直接医疗费用。
在这项随机对照试验中,38 名中重度 COPD 患者被分配到干预组或常规护理组。基于医院的干预计划提供了 8 次监督运动与 8 次自我管理教育课程相结合,为期 1 个月。主要终点是 6 分钟步行距离(6MWD),次要终点是健康相关生活质量(HRQoL)——使用圣乔治呼吸问卷(SGRQ)和诺丁汉健康问卷(NHP),最大运动能力和医疗保健利用情况。在方案实施前和 1 年后收集数据。
12 个月后,我们发现干预组在 6MWD(+50.5m(95%CI,2 至 99)、NHP 两个领域(能量,-19.8(-38 至-1);情绪反应,-10.4(-20 至 0))、SGRQ-症状(-14.0(-23 至-5))和 COPD 药物治疗费用(-480.7 欧元(CI,-891 至-70)/患者/年)方面存在统计学显著的组间差异。
与常规护理相比,本研究中基于医院的干预措施,将监督运动与自我管理教育相结合,可显著提高患者的运动耐量和 HRQoL,并显著降低 COPD 药物治疗费用。