Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Anticancer Res. 2010 Oct;30(10):4115-21.
BACKGROUND/AIM: Biliary tract carcinoma (BTC) has extremely poor prognosis because of rapid cancer cell proliferation. The aim of this study was to clarify the significance of keratinocyte growth factor receptor (KGFR) in the proliferation of BTC.
The expression of KGFR in 34 surgical specimens of BTC was investigated by immunohistochemical staining. The effect of Ki23057, a small synthetic molecule that interrupts the autophosphorylation of KGFR, on the proliferation of human BTC cell lines was examined in vitro and in vivo.
The prognosis for BTC patients with KGFR-positive tumour was significantly poorer than that for those with KGFR-negative tumour. KGF significantly stimulated the proliferation of BTC cell lines. Ki23057 significantly decreased the growth of BTC cells in vitro and in vivo.
KGFR may play an important role in the proliferation of BTC. KGFR phosphorylation inhibitor, Ki23057, therefore appears to be therapeutically promising in BTC.
背景/目的：胆管癌（BTC）由于癌细胞快速增殖，预后极差。本研究旨在阐明角质细胞生长因子受体（KGFR）在 BTC 增殖中的意义。
通过免疫组织化学染色检测 34 例 BTC 手术标本中 KGFR 的表达。体外和体内研究了小分子合成物 Ki23057 对人 BTC 细胞系增殖的影响，该化合物可阻断 KGFR 的自身磷酸化。
KGFR 阳性肿瘤的 BTC 患者的预后明显差于 KGFR 阴性肿瘤患者。KGF 显著刺激 BTC 细胞系的增殖。Ki23057 显著减少 BTC 细胞在体外和体内的生长。
KGFR 可能在 BTC 的增殖中起重要作用。因此，KGFR 磷酸化抑制剂 Ki23057 似乎在 BTC 的治疗中具有广阔的前景。
